Substances Involved in Neurotransmission

Kapalka, George M.

doi:10.1016/b978-0-12-374927-7.00004-2

Cited by 17 publications

(13 citation statements)

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“…Our results showed a significant relationship between higher circulating glycine concentrations with a higher satiety response. Glycine is present in the nervous system and acts as a neurotransmitter binding to several receptors and inhibiting many chemical processes [ 19 ]. Its effects seem to be similar to the gamma-Aminobutyric acid (GABA) action.…”

Section: Discussionmentioning

confidence: 99%

“…Its effects seem to be similar to the gamma-Aminobutyric acid (GABA) action. An increased glycine function effect may result as a similar increment in the GABAergic neurotransmission [ 19 ]. It has been reported that low plasma concentrations of glycine are associated with obesity and T2D and that in the long-term its deficiency may be related to the origin of other metabolic disorders like insulin resistance and nonalcoholic fatty liver disease [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study

et al. 2021

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Scope: To identify a metabolomic profile related to postprandial satiety sensations involved in appetite control would help for a better understanding of the regulation of food intake. Methods and Results: A cross-sectional analysis of plasma metabolites was conducted over 151 overweight/obese adults from the “Satiety Innovation”-SATIN study, a randomized clinical trial of a 12-week weight-loss maintenance period. Postprandial satiety sensations (3 h-iAUC) were assessed by visual analogue scale (VAS) at the beginning and at the end of the study. Fasting plasma metabolites were profiled using a targeted multiplatform metabolomics approach before each appetite test meal. Associations between 124 metabolites and iAUC-satiety were assessed using elastic net linear regression analyses. The accuracy of the multimetabolite weighted models for iAUC-VAS was evaluated using a 10-fold cross-validation (CV) approach and the Pearson’s correlation coefficients were estimated. Five and three metabolites were selected in the first and the second assessments, respectively. Circulating glycine and linoleic acid concentrations were consistently and positively associated with higher iAUC-satiety in both visits. Sucrose and sphingomyelins (C32:2, C38:1) were negatively associated with iAUC-satiety in the first visit. The Pearson correlations coefficients between the metabolomic profiles and iAUC-satiety in the first and the second appetite assessments were 0.37 and 0.27, respectively. Conclusion: Higher glycine and linoleic acid were moderately but consistently associated with higher postprandial satiety in two different appetite assessments in overweight and obese subjects.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study

et al. 2021

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“…The mealy phenotype was instead rich in uridine ( Figure 4A). Uridine is a nucleoside, primarily found in sugar beets (Beta vulgaris), sugarcane (Saccharum officinarum), tomatoes (Solanum lycopersicum) and broccoli (Brassica oleracea), among others [51]. Previous work reported a higher expression of Uridine Diphosphate-glucose PyroPhosphorylase (UGlcPP) in mealy peach fruits.…”

Section: Effect Of Cold Storage On the Metabolic And Lipid Profilesmentioning

confidence: 99%

Identification of Metabolite and Lipid Profiles in a Segregating Peach Population Associated with Mealiness in Prunus persica (L.) Batsch

et al. 2020

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The peach is the third most important temperate fruit crop considering fruit production and harvested area in the world. Exporting peaches represents a challenge due to the long-distance nature of export markets. This requires fruit to be placed in cold storage for a long time, which can induce a physiological disorder known as chilling injury (CI). The main symptom of CI is mealiness, which is perceived as non-juicy fruit by consumers. The purpose of this work was to identify and compare the metabolite and lipid profiles between two siblings from contrasting populations for juice content, at harvest and after 30 days at 0 • C. A total of 119 metabolites and 189 lipids were identified, which showed significant differences in abundance, mainly in amino acids, sugars and lipids. Metabolites displaying significant changes from the E1 to E3 stages corresponded to lipids such as phosphatidylglycerol (PG), monogalactosyldiacylglycerol (MGDG) and lysophosphatidylcholines (LPC), and sugars such as fructose 1 and 1-fructose-6 phosphate. These metabolites might be used as early stage biomarkers associated with mealiness at harvest and after cold storage.

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“…The mealy phenotype was instead rich in uridine ( Figure 4A). Uridine is a nucleoside, primarily found in sugar beets (Beta vulgaris), sugarcane (Saccharum officinarum), tomatoes (Solanum lycopersicum), broccoli (Brassica oleracea) among others [47]. A previous work reported higher expression of Uridine Diphosphate-glucose PyroPhosphorylase (UGlcPP) in mealy peach fruits.…”

Section: Effect Of Cold Storage In the Metabolic And Lipid Profilementioning

confidence: 99%

Identification of Metabolite and Lipid Profile in a Segregating Peach Population Associated with Mealiness in Peach

Lillo-Carmona¹,

Espinoza²,

Rothkegel³

et al. 2020

Preprint

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Peach is the third most important temperate fruit crop considering fruit production and harvested area in the world. Exporting peaches represents a challenge due to the long-distance export markets. This requires fruit to be placed in cold storage for a long time, which can induce a physiological disorder known as chilling injury (CI). The main symptom of CI is mealiness which is perceived as non-juicy fruit by consumers. The purpose of this work was to identify and compare the metabolic and lipid profile between two siblings from a contrasting population for juice content, at harvest and after 30 days at 0°C. A total of 119 metabolites and 189 lipids were identified, which showed significant differences of abundance including mainly in amino acids, sugars and lipids. Our results indicate that some of the top metabolites and lipids could be used as biomarkers associated with mealiness at harvest and after cold storage.

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Substances Involved in Neurotransmission

Cited by 17 publications

References 0 publications

Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study

Circulating Metabolites Associated with Postprandial Satiety in Overweight/Obese Participants: The SATIN Study

Identification of Metabolite and Lipid Profiles in a Segregating Peach Population Associated with Mealiness in Prunus persica (L.) Batsch

Identification of Metabolite and Lipid Profile in a Segregating Peach Population Associated with Mealiness in Peach

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