Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus: Implications for abnormal motor behavior

Anaya-Martı́nez, Verónica; Martı́nez-Marcos, Alino; Martínez‐Fong, Daniel; Aceves, Jorge; Erlij, David

doi:10.1016/j.neuroscience.2006.08.033

Cited by 51 publications

(40 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TRN receives GABAergic projections from GP, SNr, and basal forebrain (Anaya-Martinez et al 2006;Asanuma 1994;Asanuma and Porter 1990;Bickford et al 1994). In addition, TRN neurons form intra-TRN connections via axon collaterals (Huntsman et al 1999;Shu and McCormick 2002).…”

Section: Discussionmentioning

confidence: 99%

“…Alterations in thalamic DA receptors are also implicated in various neurological and psychiatric disorders (Behrendt 2006;Buchsbaum et al 2006;Di Chiara 2002;Kane et al 2009;Takahashi et al 2006;Yasuno et al 2004). Anatomical studies have shown that TRN receives a dopaminergic innervation from the substantia nigra pars compacta (SNc) (Anaya-Martinez et al 2006;Gandia et al 1993;Garcia-Cabezas et al 2007Sanchez-Gonzalez et al 2005) and expresses DA receptors (Khan et al 1998;Mrzljak et al 1996). In addition, TRN receives GABAergic projections from globus pallidus (GP), substantia nigra pars reticulata (SNr), and basal forebrain (Anaya-Martinez et al 2006;Asanuma and Porter 1990;Asanuma 1994;Bickford et al 1994;Gandia et al 1993;Hazrati and Parent 1991;Pare et al 1990).…”

Section: Introductionmentioning

confidence: 99%

“…Anatomical studies have shown that TRN receives a dopaminergic innervation from the substantia nigra pars compacta (SNc) (Anaya-Martinez et al 2006;Gandia et al 1993;Garcia-Cabezas et al 2007Sanchez-Gonzalez et al 2005) and expresses DA receptors (Khan et al 1998;Mrzljak et al 1996). In addition, TRN receives GABAergic projections from globus pallidus (GP), substantia nigra pars reticulata (SNr), and basal forebrain (Anaya-Martinez et al 2006;Asanuma and Porter 1990;Asanuma 1994;Bickford et al 1994;Gandia et al 1993;Hazrati and Parent 1991;Pare et al 1990). Inhibitory innervations within TRN arise from local collaterals (Deleuze and Huguenard 2006;Lam et al 2006;Shu and McCormick 2002).…”

Section: Introductionmentioning

confidence: 99%

“…Inhibitory innervations within TRN arise from local collaterals (Deleuze and Huguenard 2006;Lam et al 2006;Shu and McCormick 2002). GABAergic terminals within TRN are hypothesized to express D 4 receptors (Ariano et al 1997;Defagot et al 1997;Mrzljak et al 1996); however, the action of DA on GABAergic inhibitory signaling in TRN has not been explored. In this study, we found that DA, via presynaptic D 4 receptors, selectively suppresses GABA A -receptor mediated inhibition arising from GP efferents without altering intra-TRN inhibitory signaling.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Regulation of Inhibitory Synapses by Presynaptic D₄ Dopamine Receptors in Thalamus

Govindaiah

Wang

Gillette

et al. 2010

Journal of Neurophysiology

View full text Add to dashboard Cite

Govindaiah G, Wang T, Gillette MU, Crandall SR, Cox CL. Regulation of inhibitory synapses by presynaptic D 4 dopamine receptors in thalamus. J Neurophysiol 104: 2757-2765. First published September 8, 2010 doi:10.1152/jn.00361.2010 receptors are the principal targets of drugs used in the treatment of schizophrenia. Among the five DA receptor subtypes, the D 4 subtype is of particular interest because of the relatively high affinity of the atypical neuropleptic clozapine for D 4 compared with D 2 receptors. GABA-containing neurons in the thalamic reticular nucleus (TRN) and globus pallidus (GP) express D 4 receptors. TRN neurons receive GABAergic afferents from globus pallidus (GP), substantia nigra pars reticulata (SNr), and basal forebrain as well as neighboring TRN neuron collaterals. In addition, TRN receives dopaminergic innervations from substantia nigra pars compacta (SNc); however, the role of D 4 receptors in neuronal signaling at inhibitory synapses is unknown. Using whole cell recordings from in vitro pallido-thalamic slices, we demonstrate that DA selectively suppresses GABA A receptor-mediated inhibitory postsynaptic currents (IPSCs) evoked by GP stimulation. The D 2 -like receptor (D 2,3,4 ) agonist, quinpirole, and selective D 4 receptor agonist, PD168077, mimicked the actions of DA. The suppressive actions of DA and its agonists were associated with alterations in paired pulse ratio and a decrease in the frequency of miniature IPSCs, suggesting a presynaptic site of action. GABA A receptor agonist, muscimol, induced postsynaptic currents in TRN neurons were unaltered by DA or quinpirole, consistent with the presynaptic site of action. Finally, DA agonists did not alter intra-TRN inhibitory signaling. Our data demonstrate that the activation of presynaptic D 4 receptors regulates GABA release from GP efferents but not TRN collaterals. This novel and selective action of D 4 receptor activation on GP-mediated inhibition may provide insight to potential functional significance of atypical antipsychotic agents. These findings suggest a potential heightened TRN neuron activity in certain neurological conditions, such as schizophrenia and attention deficit hyperactive disorders.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Regulation of Inhibitory Synapses by Presynaptic D₄ Dopamine Receptors in Thalamus

Govindaiah

Wang

Gillette

et al. 2010

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

“…Beside the major glutamatergic projections from cortex and thalamus, the Rt receives dopaminergic input from collaterals of nigrostriatal fibers (Anaya-Martinez et al, 2006). Dopaminergic innervation of the Rt was investigated by double immunohistochemistry for PV and tyrosine hydroxylase (TH), a marker for dopaminergic cell bodies and fibers.…”

Section: Dopaminergic Innervation Of the Rtmentioning

confidence: 99%

Thalamocortical Pathfinding Defects Precede Degeneration of the Reticular Thalamic Nucleus in Polysialic Acid-Deficient Mice

Schiff¹,

Röckle²,

Burkhardt³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

IVϪ/Ϫ ) mice characterized by severe defects of major brain axon tracts, including internal capsule hypoplasia. Here, we demonstrate that misguidance of thalamocortical fibers and deficiencies of corticothalamic connections contribute to internal capsule defects in II Ϫ/Ϫ IV Ϫ/Ϫ mice. Thalamocortical fibers cross the primordium of the reticular thalamic nucleus (Rt) at embryonic day 14.5, before they fail to turn into the ventral telencephalon, thus deviating from their normal trajectory without passing through the internal capsule. At postnatal day 1, a reduction and massive disorganization of fibers traversing the Rt was observed, whereas terminal deoxynucleotidyl transferase dUTP nick end labeling and cleaved caspase-3 staining indicated abundant apoptotic cell death of Rt neurons at postnatal day 5. Furthermore, during postnatal development, the number of Rt neurons was drastically reduced in 4-week-old IIN Ϫ/Ϫ triple knock-out animals displaying no internal capsule defects. Thus, degeneration of the Rt in II Ϫ/Ϫ IV Ϫ/Ϫ mice may be a consequence of malformation of thalamocortical and corticothalamic fibers providing major excitatory input into the Rt. Indeed, apoptotic death of Rt neurons could be induced by lesioning corticothalamic fibers on whole-brain slice cultures. We therefore propose that anterograde transneuronal degeneration of the Rt in polysialylation-deficient, NCAM-positive mice is caused by defective afferent innervation attributable to thalamocortical pathfinding defects.

show abstract

Motor Control: Pyramidal, Extrapyramidal, and Limbic Motor Control

McFarland

2009

Handbook of Neuroscience for the Behavioral Sciences

View full text Add to dashboard Cite

Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus: Implications for abnormal motor behavior

Cited by 51 publications

References 61 publications

Regulation of Inhibitory Synapses by Presynaptic D₄ Dopamine Receptors in Thalamus

Regulation of Inhibitory Synapses by Presynaptic D₄ Dopamine Receptors in Thalamus

Thalamocortical Pathfinding Defects Precede Degeneration of the Reticular Thalamic Nucleus in Polysialic Acid-Deficient Mice

Motor Control: Pyramidal, Extrapyramidal, and Limbic Motor Control

Contact Info

Product

Resources

About

Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus: Implications for abnormal motor behavior

Cited by 51 publications

References 61 publications

Regulation of Inhibitory Synapses by Presynaptic D4 Dopamine Receptors in Thalamus

Regulation of Inhibitory Synapses by Presynaptic D4 Dopamine Receptors in Thalamus

Thalamocortical Pathfinding Defects Precede Degeneration of the Reticular Thalamic Nucleus in Polysialic Acid-Deficient Mice

Motor Control: Pyramidal, Extrapyramidal, and Limbic Motor Control

Contact Info

Product

Resources

About

Regulation of Inhibitory Synapses by Presynaptic D₄ Dopamine Receptors in Thalamus

Regulation of Inhibitory Synapses by Presynaptic D₄ Dopamine Receptors in Thalamus