Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease

Liu, Wenyue; Wang, Changpeng; He, Ting; Su, Minghong; Lü, Yuan; Zhang, Guanyu; Münte, Thomas F.; Jin, Lirong; Zheng, Yuxiao

doi:10.1523/jneurosci.0242-21.2021

Cited by 15 publications

(11 citation statements)

References 58 publications

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“…and Y.L.). They manually identified the LC and SN in the native space to avoid potential distortion in normalization following previous studies ( Li et al, 2019 , Liu et al, 2021 , Prasuhn et al, 2021 ).…”

Section: Methodsmentioning

confidence: 99%

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Locus coeruleus integrity correlates with inhibitory functions of the fronto-subthalamic ‘hyperdirect’ pathway in Parkinson’s disease

Lü

et al. 2022

NeuroImage: Clinical

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Section: Methodsmentioning

confidence: 99%

“…The SN was identified through a semi-automatical procedure to minimize subjective bias ( Liu et al, 2021 ). The SN was a cluster of voxels with a signal intensity that was 2.5 SDs above the mean signal intensity of the ipsilateral cerebral peduncle region (10 mm 2 each).…”

Section: Methodsmentioning

confidence: 99%

Locus coeruleus integrity correlates with inhibitory functions of the fronto-subthalamic ‘hyperdirect’ pathway in Parkinson’s disease

Lü

et al. 2022

NeuroImage: Clinical

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“…There are three core executive functions: inhibition of prepotent responses, updating of working memory representations, and shifting between tasks or mental sets (Miyake and Friedman, 2012;Miyake et al 2000). Noradrenaline has been linked to response inhibition and attentional shifting (Robbins 2007), whereas dopamine has been linked to working memory updating (Cools and D'Esposito 2011;Liu et al 2021).…”

Section: Noradrenaline and Cognitive Impairmentmentioning

confidence: 99%

Mapping neuromodulatory systems in Parkinson’s disease: lessons learned beyond dopamine

Zheng

2022

Curr Med

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Parkinson’s disease (PD) is the second most common neurodegenerative disease with mixed motor and non-motor symptoms. Dopaminergic drugs remain the mainstay of therapy for PD. However, some motor symptoms (e.g., gait problems) and a broad range of non-motor symptoms (e.g., cognitive impairment and depression) are often unresponsive to dopaminergic drugs. It is because the pathology of PD is not limited to the loss of midbrain dopamine neurons. Recent in vivo human brain imaging studies have provided novel insights into the dysfunction of multiple non-dopaminergic systems in PD. I review positron emission tomography, single photon emission computed tomography, neuromelanin-sensitive magnetic resonance imaging, and functional magnetic resonance imaging studies demonstrating the parallel alteration of noradrenergic, serotonergic, and cholinergic systems in PD. These studies shed light on the relationship between neuromodulators and vulnerable cognitive, affective, and motor functions. I finally discuss open questions in the field. More human pharmacological imaging studies are needed to reach a mechanistic understanding of the non-dopaminergic modulation of human brains.

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“… 10 In medicated patients with mild to moderate Parkinson’s disease, the caudate nucleus is additionally hypo-activated, and the ordering-related accuracy cost is driven by substantia nigra integrity. 19 …”

Section: Introductionmentioning

confidence: 99%

Altered alpha and theta oscillations correlate with sequential working memory in Parkinson’s disease

Zheng

Heldmann

Herrmann

et al. 2022

Brain Communications

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Daily activities like preparing a meal rely on the ability to arrange thoughts and actions in the right order. Patients with Parkinson’s disease have difficulties in sequencing tasks. Their deficits in sequential working memory have been associated with basal ganglia dysfunction. Here we demonstrate that altered parietal alpha and theta oscillations correlate with sequential working memory in Parkinson’s disease. We included 15 patients with Parkinson’s disease (6 women, mean age 66.0 years), 24 healthy young (14 women, mean age 24.1 years), and 16 older participants (7 women, mean age 68.6 years). All participants completed a picture ordering task with scalp EEG recording, where they arranged five pictures in a specific order and memorized them over a delay. When encoding and maintaining picture sequences, patients with Parkinson’s disease showed a lower baseline alpha peak frequency with higher alpha power than healthy young and older participants. Patients with a higher baseline alpha power responded more slowly for ordered trials. When manipulating picture sequences, patients with Parkinson’s disease showed a lower frequency of maximal power change for random versus ordered trials (Fmax) than healthy young and older participants. Healthy older participants showed a higher Fmax than healthy young participants. Compared to patients with Fmax in the alpha band (8-15 Hz), patients with Fmax in the theta band (4-7 Hz) showed a higher ordering-related accuracy cost (random versus ordered) in the main task and tended to respond more slowly and less accurately in an independent working memory test. In conclusion, altered baseline alpha oscillations and task-dependent modulation of alpha and theta oscillations may be neural markers of poor sequential working memory in Parkinson’s disease.

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Substantia Nigra Integrity Correlates with Sequential Working Memory in Parkinson's Disease

Abstract: Major Project (2018SHZDZX05). Lirong Jin was supported by the Shanghai Municipal Science and Technology Commission (2018ZR1406500). We would like to thank Dr. Jian Wang for her comments on data analysis and Biman Xu for her assistance in data acquisition. 4

Cited by 15 publications

References 58 publications

Locus coeruleus integrity correlates with inhibitory functions of the fronto-subthalamic ‘hyperdirect’ pathway in Parkinson’s disease

Locus coeruleus integrity correlates with inhibitory functions of the fronto-subthalamic ‘hyperdirect’ pathway in Parkinson’s disease

Mapping neuromodulatory systems in Parkinson’s disease: lessons learned beyond dopamine

Altered alpha and theta oscillations correlate with sequential working memory in Parkinson’s disease

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