“…Therefore the number of patients modelled in our study is of the expected order compared to the literature. We have opted to use data relating to patients with "primary" diagnosis of heart failure, as nationally in the UK and in the literature [2,3,8,15,41,42], the use of primary diagnosis is well-established for estimates of heart failure disease burden, and local policy makers will be familiar with such use of the data. We have however addressed the potential for under-estimation of true disease burden, and, subsequently, the potential underestimation of the impact of modelled interventions through sensitivity analysis.…”