Substituent-dependent fluorescent sensors for zinc ions based on carboxamidoquinoline

Guo, Xiangfeng; Jia, Lei; Xu, Shicheng; Xu, Zhi-Hui; Zheng, Libo; Qian, Xuhong

doi:10.1039/c2dt31139a

Cited by 53 publications

(20 citation statements)

References 99 publications

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“…While a 32-fold fluorescence enhancement of OAQ at 490 nm was observed when Zn 2+ was added, which mainly resulted from the coordinating OAQ to Zn 2+ and alone with the deprotonation of the amide group. [25,27]. Furthermore, the effect of Zn 2+ and Cd 2+ on absorption spectra of OAQ was compared.…”

Section: Methodsmentioning

confidence: 99%

An oxalamidoquinoline-based fluorescent sensor for selective detection of Zn2+ in solution and living cells and its logic gate behavior

Tian

Guo

et al. 2016

Sensors and Actuators B: Chemical

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Section: Methodsmentioning

confidence: 99%

An oxalamidoquinoline-based fluorescent sensor for selective detection of Zn2+ in solution and living cells and its logic gate behavior

Tian

Guo

et al. 2016

Sensors and Actuators B: Chemical

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“…Regarding interferences studied, no other transition metals interfered at all except for Cu 2+ [92]. A series highly soluble of the carboxamidoquinoline-based fluorophore on the recognition of Zn 2+ ion in aqueous buffer was investigated ( Figure 7) [93]. They reported the affinity's influences of four different substituents and three various sites on the quinoline ring.…”

Section: Aminoquinoline As a Fluorophore For Zinc's Recognitionmentioning

confidence: 99%

The Role of 8-Amidoquinoline Derivatives as Fluorescent Probes for Zinc Ion Determination

Mohamad

Zakaria

Daud

et al. 2021

Sensors

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Mass-spectrometry-based and X-ray fluorescence-based techniques have allowed the study of the distribution of Zn2+ ions at extracellular and intracellular levels over the past few years. However, there are some issues during purification steps, sample preparation, suitability for quantification, and the instruments’ availability. Therefore, work on fluorescent sensors based on 8-aminoquinoline as tools to detect Zn2+ ions in environmental and biological applications has been popular. Introducing various carboxamide groups into an 8-aminoquinoline molecule to create 8-amidoquinoline derivatives to improve water solubility and cell membrane permeability is also a recent trend. This review aims to present a general overview of the fluorophore 8-aminoquinoline and its derivatives as Zn2+ receptors for zinc sensor probes. Various fluorescent chemosensor designs based on 8-amidoquinoline and their effectiveness and potential as a recognition probe for zinc analysis were discussed. Based on this review, it can be concluded that derivatives of 8-amidoquinoline have vast potential as functional receptors for zinc ions primarily because of their fast reactivity, good selectivity, and bio-compatibility, especially for biological applications. To better understand the Zn2+ ion fluorophores’ function, diversity of the coordination complex and geometries need further studies. This review provides information in elucidating, designing, and exploring new 8-amidoquinoline derivatives for future studies for the improvement of chemosensors that are selective and sensitive to Zn2+.

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“…305 The imbalance of Zn 2+ rather excess or declined is linked to severe neurological disorders growth defects. 315 Research into zinc recognition has expanded in recent decades to encompass many areas of chemistry; from small molecule sensors to peptidebased systems and elaborate supramolecular complexes. [309][310][311][312] Contrary to these structural and functional applications, a high level of zinc is cytotoxic and may lead to skin disease, diabetes, prostatic adenocarcinoma and pancreatic islets could play critical roles in insulin biosynthesis, storage, and secretion.…”

Section: Zinc Ion Sensormentioning

confidence: 99%

Optical sensor: a promising strategy for environmental and biomedical monitoring of ionic species

2015

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There is fast growing research on designing and improving the metal recognition methodologies in the ecosystems and biological media. The fluorescent based techniques proved a mile stones for non-invasive metal sensation and quantification in the multichannel environment. Metals as the natural components of Earth's crust are generally present in trace concentrations in the environmental samples where the humic substances have complexation affinity toward them. Iron, zinc and copper are the 1 st , 2 nd and 3 rd adequate elements indispensable to the body in trace playing the crucial roles in many biological processes. However, the unregulated amounts either as excess or deficient may exacerbate deterioration to the vital organs and triggered the progression of complications. Beside these three essential elements, mercury is widely considered to be one of the most hazardous pollutants and highly dangerous elements due to its recognized accumulative and toxic characters in the environment and the ecosystem. In the current scenario, we have tried to summarize the maximum amount of recently developed fluorescent signaling materials for the Cu 2+ , Fe 2+ / Fe 3+ , Zn 2+ and Hg 2+ . The spectral shifting in the molecules on metal chelation, mode of complexation and stoichiometries of resulting adducts have been discussed in detail. Furthermore, the molecules which have been reported as intracellular metal detector via bioimaging are specifically highlighted that might be useful for the design and development of cell viable and membrane permeable molecular probes in the future perspective.

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Substituent-dependent fluorescent sensors for zinc ions based on carboxamidoquinoline

Cited by 53 publications

References 99 publications

An oxalamidoquinoline-based fluorescent sensor for selective detection of Zn2+ in solution and living cells and its logic gate behavior

An oxalamidoquinoline-based fluorescent sensor for selective detection of Zn2+ in solution and living cells and its logic gate behavior

The Role of 8-Amidoquinoline Derivatives as Fluorescent Probes for Zinc Ion Determination

Optical sensor: a promising strategy for environmental and biomedical monitoring of ionic species

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