Substituent-Induced Aggregated State Electrochemiluminescence of Tetraphenylethene Derivatives

Han, Zhengang; Zhang, Yinpan; Wu, Yanxia; Li, Zhimin; Bai, Lei; Huo, Shuhui; Lu, Xiaoquan

doi:10.1021/acs.analchem.9b02357

Cited by 76 publications

(68 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The aggregation-induced emission (AIE) results from the restriction of intramolecular motions, vibrations, and rotations . AIE carves out a new avenue for the development of novel biosensors − with wide applications in biomedical research . The metal nanocrystal-mediated AIE has been first discovered in organic molecules that possesses a propeller-like structure .…”

mentioning

confidence: 99%

A Host–Guest Interaction-Based and Metal–Organic Gel-Based Biosensor with Aggregation-Induced Electrochemiluminescence Enhancement for Methyltransferase Assay

Cui

Zhao

et al. 2021

Anal. Chem.

View full text Add to dashboard Cite

Metal−organic gels (MOGs) are new soft materials with the characteristics of high colloidal stability, superb luminescence properties, and facile synthesis. Herein, we develop for the first time a host−guest interaction-based and MOG-based biosensor with aggregation-induced electrochemiluminescence (ECL) enhancement for M.SssI methyltransferase (M.SssI MTase) assay. This biosensor employs a MOG as the luminophor and potassium persulfate as the coreactant, and the formation of the Ag-MOG from the aggregation of silver nanoclusters can induce significant ECL enhancement. Two complementary single-stranded DNAs (ssDNAs, i.e., biotinylated DNA-1 and Fc-labeled DNA-2) that contain specific recognition sequence 5′-CCGG-3′ can form a double-stranded DNA (dsDNA) probe. In the absence of M.SssI MTase, the dsDNA probe will be digested by restriction endonuclease HpaII, leading to the release of Fc from magnetic beads (MBs). The β-CD can specifically recognize the released Fc through guest−host interaction, resulting in the quenching of an ECL signal. In contrast, the presence of M.SssI MTase enables the formation of fully methylated dsDNA, which cannot be cleaved by HpaII, making Fc remain on the MB surface and consequently generating an improved ECL signal. This biosensor can specifically detect M.SssI MTase with a linear range of 0.05−100 U mL −1 and a limit of detection of 3.5 × 10 −3 U mL −1 , and it enables accurate detection of M.SssI MTase in human serum. In addition, it can be used for inhibitor screening, with wide applications in drug discovery and disease diagnosis.

show abstract

mentioning

confidence: 99%

A Host–Guest Interaction-Based and Metal–Organic Gel-Based Biosensor with Aggregation-Induced Electrochemiluminescence Enhancement for Methyltransferase Assay

Cui

Zhao

et al. 2021

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…[37] The molecular optical range is determined based on the energy difference between the highest occupied molecular orbital (HOMO) and the lowest unoccupied molecular orbital (LUMO) in most case. [95,96] The introduction of electron donor (D) to conjugate system will push HOMO upward, and adding acceptor (A) groups will reduce LUMO. [32,97] Because the twisted structure of D-A structure is facilitated to suppress the serious 𝜋-𝜋 intermolecular interactions, a series of NIR AIEgens were constructed by different types of D-A structure.…”

Section: The Design Of Aiegensmentioning

confidence: 99%

PEG‐Polymer Encapsulated Aggregation‐Induced Emission Nanoparticles for Tumor Theranostics

Dai

Dong

Wang

et al. 2021

Adv Healthcare Materials

View full text Add to dashboard Cite

In the field of tumor imaging and therapy, the aggregation-caused quenching (ACQ) effect of fluorescent dyes at high concentration is a great challenge. In this regard, the aggregation-induced emission luminogens (AIEgens) show great potential, since AIEgens effectively overcome the ACQ effect and have better fluorescence quantum yield, photobleaching resistance, and photosensitivity. Polyethylene glycol (PEG)-polymer is the most commonly used carrier to prepare nanoparticles (NPs). The advantage of PEGylation is that it can greatly prolong the metabolic half-life and reduce immunogenicity and toxicity. Considering that the hydrophobicity of most AIEgens hinders their application in organisms, the use of PEG-polymer encapsulation is an effective strategy to overcome this obstacle. Importantly, bioactive functional groups can be modified on PEG-polymers to enhance the biological effect of NPs. The combination of powerful AIEgens and PEG-polymers provides a new strategy for tumor imaging and therapy, which is promising for clinical application.

show abstract

“…4d) [47]. These BSA-TPE NCs were further used for developing a highly sensitive and selective biosensor for the detection of miRNA-141 [50] Chemical modification of TPE has shown to be a powerful strategy not only for the tuning of the aggregation and emission properties of the materials but, as shown by Lu et al [51], because it represents a simple way to produce sensing platforms in the aqueous phase. Functionalization of TPE, i.e.…”

Section: Small Molecule-based Aieclmentioning

confidence: 99%

Aggregation-Induced Emission in Electrochemiluminescence: Advances and Perspectives

2021

View full text Add to dashboard Cite

The discovery of aggregation-induced electrochemiluminescence (AIECL) in 2017 opened new research paths in the quest for novel, more efficient emitters and platforms for biological and environmental sensing applications. The great abundance of fluorophores presenting aggregation-induced emission in aqueous media renders AIECL a potentially powerful tool for future diagnostics. In the short time following this discovery, many scientists have found the phenomenon interesting, with research findings contributing to advances in the comprehension of the processes involved and in attempts to design new sensing platforms. Herein, we explore these advances and reflect on the future directions to take for the development of sensing devices based on AIECL. Graphic abstract

show abstract

Substituent-Induced Aggregated State Electrochemiluminescence of Tetraphenylethene Derivatives

Cited by 76 publications

References 47 publications

A Host–Guest Interaction-Based and Metal–Organic Gel-Based Biosensor with Aggregation-Induced Electrochemiluminescence Enhancement for Methyltransferase Assay

A Host–Guest Interaction-Based and Metal–Organic Gel-Based Biosensor with Aggregation-Induced Electrochemiluminescence Enhancement for Methyltransferase Assay

PEG‐Polymer Encapsulated Aggregation‐Induced Emission Nanoparticles for Tumor Theranostics

Aggregation-Induced Emission in Electrochemiluminescence: Advances and Perspectives

Contact Info

Product

Resources

About