Substituted Guanidines:  Introducing Diversity in Combinatorial Chemistry

Abstract

The guanidine moiety is an important motif present in many biologically active compounds. Fully substituted guanidines are of key importance for the development of bioactive molecules. The present paper reports on an efficient procedure for the direct solid-phase conversion of amines to fully substituted guanidines under very mild conditions.

A Re‐evaluation of the Use of Rink, BAL, and PAL Resins and Linkers

“…Triethylamine (3 equiv) and commercial available guanidium derivatives (3 equiv) were disssolved in DCM and added to the resin. The mixture was stirred overnight at 25 8C [26].…”

Methods for the Peptide Synthesis and Analysis

“…This occurs for N- [116][117][118][119][120][121][122]. NMR studies in the case of HAPyU show that the same structure is found in solution [113,116] (Figure 2.9).…”

Conformationally Restricted Hydantoin‐Based Peptidomimetics as Inhibitors of Caspase‐3 with Basic Groups Allowed at the S3 Enzyme Subsite

“…Next, we examined distinct substitutions of the guanidine group in the Arg side chain. Analogues of 15 a with electron-withdrawing groups such as aromatic sulfonyl groups (in [16][17][18], or nitrated 19, as well as compounds with tetraalkylated guanidines 20-24 were synthesized. Electron-deficient guanidine compounds 16-19, including the one that was only nitrated (compound 19), showed similar activity to that of 15 a ( Table 2).…”