Substituted Pyrazolo[3,4-B]Pyridin-3-Ones and Pyrazolo[3,4-B]Pyridine-5- Carbaldehyde, New One-Pot Synthesis Strategy Amelioration Using Vinamidinium Salts, Antibacterial and Antifungal Activities Promising Environmental Protection

Abstract

This review summarizes the current knowledge about the syntheses and biological behavior of some pyrazolo [5,4-b]pyridines. So, an expedient method for the synthesis of 2-phenyl-5-aryl-1,6-dihydropyrazolo [3,4-b]pyridin-3-ones and 2-phenyl-3-oxo-1,6-dihydropyrazolo[3,4-b]pyridine-5-carbaldehyde in a single-step via condensation of vinamidinium salts with 3-amino-1-phenyl-2-pyrazolin-5-one is described according to our recent study with synthesis strategy amelioration. Five derivatives (PYR 1-5 ) were prepared and characterized by spectral data (NMR and MS spectral studies). All the derivatives were studied for their antimicrobial activities. So, we screened for antibacterial effects at 1:2, and 1:4 dilutions by the paper disc diffusion method against respectively Bacteria (Escherichia coli CIP 53126 and Bacillus subtilis CIP 5262) and Fungi (Candida albicans ATCC 10231). Then, we screened for Fungi (Aspergillus niger ATCC 16404) by the dilution method (agar and liquid broth). The agar diffusion method (paper disc and well) and the dilution method (agar and liquid broth) are described.

Pyrazole derivatives of pyridine and naphthyridine as proapoptotic agents in cervical and breast cancer cells

“…Pyrazolo-pyridine derivatives have been shown to be antimalarial, antiviral, anti-leishmanial, anti-tubercular, anti-leukemic, antifungal, anxiolytic, osteogenic and have, antitumor activity. Moreover, they have also been studied in management of drug and alcohol addiction, Alzheimer’s disease, infertility and gastrointestinal diseases 14 . Mohamed et al 15 synthesized pyrazolo-cyanopyridine derivatives having antitumor activity.…”

Green synthesis and anticancer activity of tetrahydrodipyrazolo[3,4‐b:4′,3′‐e]pyridines catalyzed by phospho sulfonic acid

“…Furthermore, other bioactive N-containing heterocyclic compounds have been synthesized with a well-known pyrazolopyridine scaffold [20][21][22] and they have numerous pharmacological activities, like, antivirus, antifungal, antimicrobial, antibacterial, antitumor, cancer cell growth inhabitation activities, protein kinase inhibitors, anti-Leishmania, PDE4B inhibitors, B-Raf V600E3 inhibitors, dopaminergic properties, HIF 1-α-prolyl hydroxylase inhibitors. [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] On the other hand, tetrahydrodipyrazolopyridines are also another interesting class of fused heterocycles because of their wide range of biological activities. [39][40][41][42][43][44] In this connection, in the literature, several authors reported many pyrazolopyridine derivatives by innovative methods.…”

Iron oxide magnetic nanoparticles supported on amino propyl‐functionalized KCC‐1 as robust recyclable catalyst for one pot and green synthesis of tetrahydrodipyrazolopyridines and cytotoxicity evaluation

“…Pyrazolopyridines represent a well‐known scaffold in various bioactive compounds and have numerous pharmacological properties. These compounds exhibit important biological properties, including antibacterial, antimicrobial, antifungal, antitumor, anti‐virus, anti‐Leishmania, HIF 1‐αprolyl hydroxylase inhibitors, B‐Raf V600E3 inhibitors, protein kinase inhibitors, PDE4B inhibitors, dopaminergic properties and cancer cell growth inhabitation activities . The main problems for the synthesis of pyrazolopyridine compounds are long reaction times, utilize of non‐reusable and toxic catalyst and use of particular conditions.…”