Substituted quinolines induce inhibition of proliferation of HTLV-1 infected cells

Fournet, Alain; Mahieux, Renaud; Fakhfakh, M.; Franck, Xavier; Hocquemiller, Reynald; Figadère, Bruno

doi:10.1016/s0960-894x(02)01085-5

Cited by 66 publications

(12 citation statements)

References 17 publications

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“…Some typical examples are exemplified by Figure 1. Compound a was isolated from Stigmatella aurantiaca and utilized as a potent antibiotic,5 compound b is a novel and potent human CCR8 antagonist,6 while compound c has the efficient biological activity to induce inhibition of proliferation of HTLV‐1 infected cells 7…”

Section: Methodsmentioning

confidence: 99%

Direct C‐2 Alkylation of Quinoline N‐Oxides with Ethers via Palladium‐Catalyzed Dehydrogenative Cross‐Coupling Reaction

Cui

et al. 2013

Adv Synth Catal

141

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Section: Methodsmentioning

confidence: 99%

Direct C‐2 Alkylation of Quinoline N‐Oxides with Ethers via Palladium‐Catalyzed Dehydrogenative Cross‐Coupling Reaction

Cui

et al. 2013

Adv Synth Catal

141

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“…In addition, compound 203 showed excellent growth inhibition of influenza virus 288. 2-(3,4-Methylenedioxyphenethyl)quinoline(124), chimanine D (122), 2-pentylquinoline (120), and 2-nproplyquinoline (119) from G. longiflora inhibited the growth of cells infected with human T-lymphotropic virus type 1 (HLTV-1) [289][290][291]. Certain quinolines also showed antiproliferative activity against HTLV-1 infected HUT-102 cells.…”

mentioning

confidence: 99%

Biologically active quinoline and quinazoline alkaloids part I

Shang

Morris‐Natschke

Liu

et al. 2017

Medicinal Research Reviews

320

166

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Quinoline and quinazoline alkaloids, two important classes of N-based heterocyclic compounds, have attracted tremendous attention from researchers worldwide since the 19th century. Over the past 200 years, many compounds from these two classes were isolated from natural sources, and most of them and their modified analogs possess significant bioactivities. Quinine and camptothecin are two of the most famous and important quinoline alkaloids, and their discoveries opened new areas in antimalarial and anticancer drug development, respectively. In this review, we survey the literature on bioactive alkaloids from these two classes and highlight research achievements prior to the year 2008 (Part I). Over 200 molecules with a broad range of bioactivities, including antitumor, antimalarial, antibacterial and antifungal, antiparasitic and insecticidal, antiviral, antiplatelet, anti-inflammatory, herbicidal, antioxidant and other activities, were reviewed. This survey should provide new clues or possibilities for the discovery of new and better drugs from the original naturally occurring quinoline and quinazoline alkaloids.

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“…We therefore propose to focus on quinoline 5 for industrial development with companies from areas of endemicity. The in vitro antiretroviral properties of the compounds tested in this study have been recently demonstrated against HIV-1 (9) and against human T-cell leukemia virus type 1 (12,13), suggesting that the most promising compounds could be used for HIV-leishmaniasis coinfection. Their preparation by chemical synthesis is easily transposable in emerging countries with an industrial partner which could produce them on a large scale at low cost.…”

Section: Vol 49 2005 Efficacy Of 2-substituted Quinolines In Leishmmentioning

confidence: 80%

“…Furthermore, quinoline 5 was evaluated ex vivo for its antiviral activity against HIV-1 replication in CEM4fx cells. In this case, it exhibited submicromolar antiviral activity (IC 50 of around 1 M) and also showed some activity against human T-cell leukemia virus type 1-infected cells (12,13). Cutaneous and visceral leishmaniasis remain a therapeutic challenge and a serious public health problem.…”

Section: Vol 49 2005 Efficacy Of 2-substituted Quinolines In Leishmmentioning

confidence: 92%

Efficacy of Orally Administered 2-Substituted Quinolines in Experimental Murine Cutaneous and Visceral Leishmaniases

Nakayama

Loiseau

Bories

et al. 2005

Antimicrob Agents Chemother

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We report in this study the in vivo efficacy of nine 2-substituted quinolines on the Leishmania amazonensis cutaneous infection murine model and on the Leishmania infantum and Leishmania donovani visceral infection murine models. In the case of the L. amazonensis model, quinolines were administered orally at 25 mg/kg twice daily for 15 days. Quinolines 1, 2, 3, and 7 reduced by 80 to 90% the parasite burdens in the lesion, whereas N-methylglucamine antimoniate (Glucantime), administered by subcutaneous injections at 100 mg [28 mg Sb(V)] per kg of body weight daily, reduced the parasite burdens by 98%. In visceral leishmaniasis due to L. infantum, mice treated orally at 25 mg/kg daily for 10 days with quinolines 1, 4, 5, and 6 showed a significant reduction of parasite burdens in the liver and spleen. These quinolines were significantly more effective than meglumine antimoniate to reduce the parasite burden in both the liver and spleen. Also, the oral in vivo activity of three quinolines (quinolines 4, 5, and 2-n-propylquinoline) were determined against L. donovani (LV 9) at 12.5 and 25 mg/kg for 10 days. Their activity was compared with that of miltefosine at 7.5 mg/kg. Miltefosine, 2-n-propylquinoline, and quinoline 5 at 12.5 mg/kg significantly reduced the parasite burdens in the liver by 72, 66, and 61%, respectively. From the present study, quinoline 5 is the most promising compound against both cutaneous and visceral leishmaniasis. The double antileishmanial and antiviral activities of these compounds suggest that this series could be a potential treatment for coinfection of Leishmania-human immunodeficiency virus.

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Substituted quinolines induce inhibition of proliferation of HTLV-1 infected cells

Cited by 66 publications

References 17 publications

Direct C‐2 Alkylation of Quinoline N‐Oxides with Ethers via Palladium‐Catalyzed Dehydrogenative Cross‐Coupling Reaction

Direct C‐2 Alkylation of Quinoline N‐Oxides with Ethers via Palladium‐Catalyzed Dehydrogenative Cross‐Coupling Reaction

Biologically active quinoline and quinazoline alkaloids part I

Efficacy of Orally Administered 2-Substituted Quinolines in Experimental Murine Cutaneous and Visceral Leishmaniases

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