Food processes have been requiring increasingly more accurately designed operations. Successful design results in products with high quality, in addition to offering energy and cost savings. To these ends, fundamental knowledge regarding the physical properties and thermodynamic mechanisms of the material is essential. The aim of this review was to highlight important concepts and applications of some thermophysical properties (density, specific heat, thermal conductivity and thermal diffusivity), as well as recent methods for their determination. The rheology of fluids and solids is widely discussed according to the concepts, classification, modeling and applications involved in food and equipment design. Herein, we report destructive and non-destructive assays for the evaluation of food properties. Due to the complexity of food systems, the effects of modifications of the structure and physicochemical reactions on the quality of the resulting food are addressed based on thermodynamic aspects. This analytical perspective was adopted in food systems rich in fats, proteins, polysaccharides and simple sugars. Using the information reported in this study, formulations and unit operations can be better designed. In addition, process failures become more predictable when fundamental knowledge is available. Therefore, food losses can be avoided, quality can be maintained and operations can be effectively resumed when deviations from ideal conditions are evidenced.