Substrate‐Controlled Transformation: Diastereoselective Functionalization

Transition Metal‐Catalyzed Enantioselective C−H Functionalization via Chiral Transient Directing Group Strategies

“…To this end, the recent developments of chiral transient directing group (cTDG) strategy have demonstrated to be a promising alternative since it obviates the lengthy steps to install and remove external DGs in traditional directing group-assisted processes. [6] In addition, compared to the diastereoselective CÀH functionalization strategy that relies on the use of stoichiometric, covalently attached chiral DG, [7] the cTDG strategy involves the use of catalytic chiral organocatalyst for the in situ formation of a transient chiral auxiliary, which serves as an efficient DG to coordinate with metal catalyst to enable C À H cleavage and ensure chiral induction during or after the C À H cleavage step. A generic catalytic cycle was summarized in Scheme 1 B.…”