Substrate‐Dependent Stereoselective Synthesis of Pyrrolo[3,4‐b]Pyridin‐5‐Ones and Pyridyl Isoindoline‐1‐Ones Using Bis(benzotriazol‐1‐yl) Ligand

Abstract

The documented work highlighted the synthesis of bis(benzotriazol‐1‐yl) methane derivatives using silicomolybdic acid (SMA) and successfully implemented in the stereoselective synthesis of diverse pyrrolo[3,4‐b]pyridin‐5‐one and pyridyl isoindolinones derivatives in one‐pot. The pyridinamide precursor with diverse alkynes furnished Z‐selectivity of pyrrolo[3,4‐b]pyridin‐5‐one across exocyclic C=C bond while the various benzamides on treating with 2‐ethynyl pyridine afforded (E)‐pyridylisoindoline‐1‐ones as a major isomer. The single‐crystal X‐ray diffraction provides strong evidence in favor of the existence and orientation of developed compounds. The broad substrate scope, easy accessibility of substrates, high stereoselectivity, scale‐up synthesis, and crystal evidence demonstrate the merits of the current decorum.