Substrate-directed divergent synthesis of fused indole polycycles through Rh(ii)-catalyzed cascade reactions of bis(diazo)indolin-2-ones

Abstract

Herein, we report a substrate-directed diverse synthetic strategy toward two kinds of structurally intriguing fused indole polycycles through Rh(II)-catalyzed cascade reactions of bis(diazo)indolin-2-ones with enaminones. The subtle structural changes in...

Synthesis of N-fused polycyclic indoles via a Pd-catalyzed multicomponent cascade reaction consisting of an amide-directed [3+1+1] annulation reaction of 3-diazo oxindole and isocyanides

“…4 Recently, Wang and co-workers reported a cascade approach to synthesize oxazolo[3,2- a ]indolones along with indolo [2,3- b ] indoles in the presence of a rhodium catalyst at 130 °C (Scheme 1c). 5 However, most of these approaches are associated with certain limitations such as complex starting materials, longer reaction time, lower efficiency, and substrate scope.…”

Organophosphine as an Alkyl Transfer Shuttle for the Direct β-Alkylation of Chalcones Using Alkyl Halides

“…As a continuation of our research interest in designing fascinating cascade reactions to assemble structurally interesting molecules, herein, we wish to report the successful implementation of this strategy for the β-alkylation of chalcones using halogenated hydrocarbons as alkyl sources. The following features of this work meet the requirements of green organic synthesis.…”