Substrate‐Independent Coating with Persistent and Stable Antifouling and Antibacterial Activities to Reduce Bacterial Infection for Various Implants

Yuan, Pingyun; Qiu, Xinyu; Wang, Xinran; Tian, Ran; Wang, Lin; Bai, Yongkang; Liu, Shiyu; Chen, Xin

doi:10.1002/adhm.201801423

Cited by 39 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To address the issues caused by hospital-acquired infections, antibacterial materials/coatings have been developed using two main mechanisms. One is contact-based killing with bactericidal materials, , and the other is to inhibit bacterial colonization on synthetic surfaces with antifouling materials. , The two approaches are often combined to design dual-functional surfaces. , Antifouling materials can prevent nonspecific protein adsorption and bacterial adhesion on surfaces and thus inhibit subsequent biofilm formation . Poly(ethylene glycol) (PEG), zwitterionic materials, nonionic hydrophilic polymers, fluorinated polymers, and negatively charged polymers have been mostly utilized as antifouling materials. − …”

Section: Introductionmentioning

confidence: 99%

Antibacterial Film Formation through Iron(III) Complexation and Oxidation-Induced Cross-Linking of OEG-DOPA

Lee

Kim

et al. 2019

Langmuir

View full text Add to dashboard Cite

Catechols are prone to oxidative polymerization as well as complex formation with metal ions. These two features of catechols have played an important role in the construction of functional films on various surfaces. For example, marine antifouling films and antibacterial films were successfully prepared by oxidative polymerization and metal complexation of catechol-containing molecules, respectively. However, the effect of simultaneous metal complexation and oxidative polymerization on functional film formation has not yet been fully investigated. Herein, as a derivative of 3-(3,4dihydroxyphenyl)-L-alanine (DOPA), we synthesized an ethylene glycol-derivatized DOPA (OEG-DOPA) and formed OEG-DOPA thin films based on (1) oxidative polymerization and (2) the complexation between catechol groups of OEG-DOPA and iron(III) (Fe III ) ions. Either or both approaches were used for the film formation. OEG-DOPA film formation was characterized by ellipsometry, contact angle goniometry, field emission scanning electron microscopy, and X-ray photoelectron spectroscopy. Among the conditions used, the formation of a uniform film was only achieved with the dual cross-linking system of Fe III complexation and oxidation-induced covalent bond formation. Compared to the uncoated substrate and other OEG-DOPA films prepared under different conditions, the uniform OEG-DOPA film strongly inhibited bacterial adhesion, showing excellent antibacterial capability. We think that our surface-coating strategy can be applied to medical devices, tools, and implants where bacterial adhesion and biofilm formation should be prevented. This work can also serve as a basis for the construction of functional thin films for other catechol-functionalized materials.

show abstract

Section: Introductionmentioning

confidence: 99%

Antibacterial Film Formation through Iron(III) Complexation and Oxidation-Induced Cross-Linking of OEG-DOPA

Lee

Kim

et al. 2019

Langmuir

View full text Add to dashboard Cite

show abstract

“…To realize even longer lasting drug release, multilayer polyelectrolyte assemblies can be applied to release HDP over a period of weeks. [243,248,249] For instance, Riool et al produced implants coated with a polymer-lipid encapsulation matrix (PLEX) containing the LL-37-derived anti-biofilm peptides SAAP-145 and SAAP-276. The self-assembly of multiple alternating layers of polymer and phospholipid in the PLEX provided zero-order release kinetics of the SAAP peptides stretching over a period of one month, and was more potent than an antibiotic-based doxycycline-PLEX coating in reducing the bacterial numbers.…”

Section: Strategies For Hdp Biofunctionalization Of Biomaterialsmentioning

confidence: 99%

Combating Implant Infections: Shifting Focus from Bacteria to Host

et al. 2020

View full text Add to dashboard Cite

commensal skin bacteria, Staphylococci, and in particular Staphylococcus aureus, have a strong tendency to colonize foreign bodies and cause IAI. [3,4] Important for the underlying pathophysiology, Staphylococci are highly competent at producing biofilms on implant surfaces, which encapsulate the bacterial niche from the outside environment, [5,6] thereby protecting the bacteria from host defense systems and antibiotics. [7] Antibiotics are administered as a routine procedure. [8] However, as a consequence of widespread antibiotics usage, bacteria are exposed to subinhibitory concentrations of antibiotics at a larger scale, driving their development toward antibiotic resistance, [9] as illustrated by the emergence of methicillin-resistant S. aureus (MRSA). [10,11] As an improvement over current clinically applied local antibiotics delivery systems, [12] the recent developments in implant surface engineering approaches allow better antimicrobial functionalities to be incorporated to allow for more tunable and controlled drug release. [13-15] The "race to the surface" model is popular among biomaterials researchers to predict the biomaterials fate, resulting from the competition between eukaryotic cells and bacteria at the material surface. [16] Using this template, implant antibacterial properties are being stemmed from direct contact killing mechanisms due to implant surface modifications [17,18] or firm immobilization of drugs, [19,20] as they both "shield" the implant from bacterial adhesion. The current anti-infective biomaterials strategies being explored can be categorized as: 1) implant functionalization with antibiotics or antibacterial drugs such as host defense peptides (HDPs), inorganic materials (e.g., chitosan and derivatives), and inorganics (e.g., silver, copper, and zinc metal nanoparticles (NPs)), 2) anti-biofilm surface modification (e.g., coating with antifouling polymers or quorum sensor inhibitors), or 3) physical surface changes for direct contact-killing properties (e.g., nanotubes, nanopillars, and metal implantation). [15,21] Emerging as a serious alternative or adjuvant therapy to antibiotics, bacteriophage (phage) therapy uses viruses responsible for the lysis of specific bacterial strains. [22,23] As a natural predator of bacteria, phages employ different killing mechanisms, making multidrug resistant bacteria susceptible for phages. [24] Moreover, phages are highly specific for pathogenic cells, which can eliminate disastrous off-target effects in the host. [25] As a limitation, the use of phage cocktails is needed for therapeutic efficacy, [26] while there is currently is no conclusive data on possible long-term side effects of phage therapy in The widespread use of biomaterials to support or replace body parts is increasingly threatened by the risk of implant-associated infections. In the quest for finding novel anti-infective biomaterials, there generally has been a one-sided focus on biomaterials with direct antibacterial properties, which leads to excessive use of antibacterial ag...

show abstract

“…The killing efficacy against MRSA showed a 3.4 log 10 CFU (colony forming unit) reduction in the β-peptide polymer-modified TPU when compared with the unmodified TPU (Figure ). A similar S. aureus infection model was used to evaluate the in vivo antimicrobial activity of ε-PL-PEG-(PDDA/PSS) 9 coating on the quartz slide . Different from the construction method using bacterial drops on the simple flat implant surface, specific implants with approximate dimensions were often modeled using bacterial suspensions.…”

Section: In Vivo Animal Subcutaneous Implant Infection Modelmentioning

confidence: 99%

“…158 A similar S. aureus infection model was used to evaluate the in vivo antimicrobial activity of ε-PL-PEG-(PDDA/PSS) 9 coating on the quartz slide. 159 Different from the construction method using bacterial drops on the simple flat implant surface, specific implants with approximate dimensions were often modeled using bacterial suspensions. Then, complete and uniform bacterial coverage on the implant surface can enhance the rationality of the infection model.…”

Section: In Vivo Animal Subcutaneous Implantmentioning

confidence: 99%

Using In Vivo Assessment on Host Defense Peptide Mimicking Polymer-Modified Surfaces for Combating Implant Infections

Qian

Deng

et al. 2020

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

Infections have accounted for the majority of failures in implants over the past decades. Host defense peptide mimicking polymers have been considered as one of the promising antimicrobial candidates for their cost-effective synthesis, broad-spectrum antimicrobial activity, low propensity to induce drug resistance, and remarkable biocompatibility. In this review, covalent-grafting strategies are mainly discussed to tether host defense peptide mimicking polymers on surfaces, aiming to obtain potent antimicrobial activity. In addition to the antimicrobial function, we review the antimicrobial mechanism of these polymer-modified antimicrobial surfaces in precedent literatures. We also review the in vivo subcutaneous implant infection models that are critical assessments for potential biomedical applications. In the end, we provide our perspective on the future development of this field, especially for biomedical applications.

show abstract

Substrate‐Independent Coating with Persistent and Stable Antifouling and Antibacterial Activities to Reduce Bacterial Infection for Various Implants

Cited by 39 publications

References 29 publications

Antibacterial Film Formation through Iron(III) Complexation and Oxidation-Induced Cross-Linking of OEG-DOPA

Antibacterial Film Formation through Iron(III) Complexation and Oxidation-Induced Cross-Linking of OEG-DOPA

Combating Implant Infections: Shifting Focus from Bacteria to Host

Using In Vivo Assessment on Host Defense Peptide Mimicking Polymer-Modified Surfaces for Combating Implant Infections

Contact Info

Product

Resources

About