Substrate-induced assembly of cascade enzymes and catalytic surfactants: nanoarchitectonics at the oil-in-water droplet interface

Priyanka,; Kaur, Manpreet; Maiti, Subhabrata

doi:10.1039/d4cc03243h

Chem. Commun.

2024

DOI: 10.1039/d4cc03243h

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Substrate-induced assembly of cascade enzymes and catalytic surfactants: nanoarchitectonics at the oil-in-water droplet interface

Priyanka,

Manpreet Kaur,

Subhabrata Maiti

Abstract: The distribution of lipids and lipid-bound proteins is heterogeneous in plasma membrane for functional advantages. Herein, in a synthetic system, we demonstrate assembly of three enzymes involved in cascade reactions,...

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Cited by 5 publications

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Nanoarchitectonics for Biomedical Research: Post‐Nanotechnology Materials Approach for Bio‐Active Application

Ariga

2024

Advanced NanoBiomed Research

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Nanoarchitectonics, as a post‐nanotechnology concept, represents a methodology for the construction of functional materials employing atoms, molecules, and nanomaterials as essential components. The overarching objective of nanoarchitectonics is to develop functional systems comprising multiple functional units assembled in a hierarchical manner, as observed in biological systems. Nevertheless, the construction of such functional systems is a challenging endeavor. It would be prudent, therefore, to initially focus on the development of functional materials that interact with the complex functional structures of living organisms. Accordingly, this review article addresses the topic of nanoarchitecture as it pertains to biomedical applications. This article examines the current trends in research and presents examples of studies that support the concept of nanoarchitectonics and its applications in biomedical fields. The examples presented are as follows: i) molecular nanoarchitectonics developments, which are mainly based on molecular design and assembly; ii) material nanoarchitectonics examples, which are mainly based on material design using nanomaterials as components; and iii) biomedical applications with porous materials, which will be summarized under the heading of pore‐engineered nanoarchitectonics due to their special structure. Finally, the review provides an overview of these examples and discusses future prospects.

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Nanoarchitectonics for Biomedical Research: Post‐Nanotechnology Materials Approach for Bio‐Active Application

Ariga

2024

Advanced NanoBiomed Research

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Transient transition from Stable to Dissipative Assemblies in Response to the Spatiotemporal Availability of a Chemical Fuel

Kar,

Chen,

Das

et al. 2024

Angewandte Chemie

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The transition from inactive to active matter implies a transition from thermodynamically stable to energy‐dissipating structures. Here, we show how the spatiotemporal availability of a chemical fuel causes a thermodynamically stable self‐assembled structure to transiently pass to an energy‐dissipating state. The system relies on the local injection of a weak affinity phosphodiester substrate into an agarose hydrogel containing surfactant‐based structures templated by ATP. Injection of substrate leads to the inclusion of additional surfactant molecules in the assemblies leading to the formation of catalytic hotspots for substrate conversion. After the local disappearance of the substrate as a result of chemical conversion and diffusion the assemblies spontaneously return to the stable state, which can be reactivated upon the injection of a new batch of fuel. The study illustrates how a dissipating self‐assembled system can cope with the intermittent availability of chemical energy without compromising long‐term structural stability.

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Transient transition from Stable to Dissipative Assemblies in Response to the Spatiotemporal Availability of a Chemical Fuel

Kar,

Chen,

Das

et al. 2024

Angew Chem Int Ed

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Substrate-induced assembly of cascade enzymes and catalytic surfactants: nanoarchitectonics at the oil-in-water droplet interface

Abstract: The distribution of lipids and lipid-bound proteins is heterogeneous in plasma membrane for functional advantages. Herein, in a synthetic system, we demonstrate assembly of three enzymes involved in cascade reactions,...

Cited by 5 publications

References 38 publications

Nanoarchitectonics for Biomedical Research: Post‐Nanotechnology Materials Approach for Bio‐Active Application

Nanoarchitectonics for Biomedical Research: Post‐Nanotechnology Materials Approach for Bio‐Active Application

Transient transition from Stable to Dissipative Assemblies in Response to the Spatiotemporal Availability of a Chemical Fuel

Transient transition from Stable to Dissipative Assemblies in Response to the Spatiotemporal Availability of a Chemical Fuel

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