2024
DOI: 10.1021/acschemneuro.4c00068
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Substrate Selection Criteria in Regulated Intramembrane Proteolysis

Celine Moser,
Nadja Guschtschin-Schmidt,
Mara Silber
et al.

Abstract: Alzheimer's disease is the most common form of dementia encountered in an aging population. Characteristic amyloid deposits of Aβ peptides in the brain are generated through cleavage of amyloid precursor protein (APP) by γ-secretase, an intramembrane protease. Cryo-EM structures of substrate γ-secretase complexes revealed details of the process, but how substrates are recognized and enter the catalytic site is still largely ignored. γ-Secretase cleaves a diverse range of substrate sequences without a common co… Show more

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