The objective of this research is to compare the performance and economic value of TiN coated end mills and WC end mills on S45C slot milling. The commercial end mills that produce and provide by SAN Engineering and Supply Co., Ltd. and commercial S45C steels, were selected for this investigation. The models of wear were analyzed by the scanning electron microscope, SEM. The result showed that the wear models of the TiN coated end mills are abrasive and surface peeling, while the wear models of WC end mills are adhesive and uniform micro-chipping on the cutting edges. The analysis the economic value also represented that WC end mills are worth more than the others.