Subtalar arthroscopy: indications, technique, and results

Williams, M. H.; Ferkel, R. D.

doi:10.1016/s0749-8063(98)70004-0

Cited by 78 publications

(57 citation statements)

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“…Microfracture is a common clinical procedure used for the repair of cartilage defects (5). The benefits of microfracture include the fact that it is a single-stage procedure, is relatively simple from a technical point of view, is cost-effective with low patient morbidity, and involves the patients' own mesenchymal stem cells (MSCs) as a cell source to stimulate cartilage repair.…”

mentioning

confidence: 99%

“…The reparative process in microfracture involves a clot of pluripotent MSCs that adhere to the subchondral bone. Histological assessment of microfracture in animal (6,7) and clinical testing (5) have shown that most lesions form fibrous cartilage with predominant type I collagen and a limited amount of type II collagen present. Additionally, there is a significant drop in clinical outcome scores after 18 months as well as in patients older than 40 years (8).…”

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confidence: 99%

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Supramolecular design of self-assembling nanofibers for cartilage regeneration

Shah

Lim

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

501

427

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Molecular and supramolecular design of bioactive biomaterials could have a significant impact on regenerative medicine. Ideal regenerative therapies should be minimally invasive, and thus the notion of self-assembling biomaterials programmed to transform from injectable liquids to solid bioactive structures in tissue is highly attractive for clinical translation. We report here on a coassembly system of peptide amphiphile (PA) molecules designed to form nanofibers for cartilage regeneration by displaying a high density of binding epitopes to transforming growth factor β-1 (TGFβ-1). Growth factor release studies showed that passive release of TGFβ-1 was slower from PA gels containing the growth factor binding sites. In vitro experiments indicate these materials support the survival and promote the chondrogenic differentiation of human mesenchymal stem cells. We also show that these materials can promote regeneration of articular cartilage in a full thickness chondral defect treated with microfracture in a rabbit model with or even without the addition of exogenous growth factor. These results demonstrate the potential of a completely synthetic bioactive biomaterial as a therapy to promote cartilage regeneration.self-assembling biomaterials | chondral defects | microfracture | peptide amphiphiles | transforming growth factor

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mentioning

confidence: 99%

mentioning

confidence: 99%

Supramolecular design of self-assembling nanofibers for cartilage regeneration

Shah

Lim

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

501

427

View full text Add to dashboard Cite

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“…Microfracture provides at least effective short-term improvement of knee function [7]. For this reason and due to its minimally invasive nature, technical ease, limited surgical morbidity, low costs and because it does not prevent the application of other cartilage repair procedures that may be needed in the future, microfracture has gained popularity over the past two decades [8][9][10]. It is now a common first-line treatment for patients with cartilage defects of the knee [11,12].…”

Section: As Well As Tomentioning

confidence: 99%

Microfracture of the Knee: Are The Results Achieved In Clinical Practice Statistically Comparable to Those Presented in Controlled Studies?

Negrin¹,

Vécsei²

2013

UCMS

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Purpose: To proof the hypothesis that the results achieved by microfracture of the knee in clinical practice are not statistically comparable to those presented in controlled studies. Methods: Our literature search focused on patients with full-thickness cartilage defects of the knee who were treated with microfracture without implantation of a scaffold or injection of substitutes and whose functional capacity was assessed by clinical scores. Whereas these patients formed group A, group B consisted of 26 patients who had been treated at our Level I trauma center. The decision if microfracture was appropriate was made during an arthroscopy of the knee that was scheduled for the repair of meniscal and/or ligamental deficiencies. Due to missing preselection no exclusion criteria were defined. We compared the two groups by performing a correlation analysis. Results: Four randomized controlled trials and one prospective cohort study were detected which provided 187 patients for group A. Surprisingly, a very high correlation (Pearson coefficient r = 0.924, p = 0.008) was calculated between the score values, indicating similar postoperative outcome in both groups. Conclusions: Controlled studies may reflect general population results and therefore provide estimates of treatment effects which are applicable in usual clinical practice.

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“…The diagnosis of ostrigonum syndrome can be suspected from the clinical examination findings but is confirmed by radiographs showing the ostrigonum and by magnetic resonance imaging (MRI), computed tomography, and bone scans used to identify other bony and soft-tissue involvement [10] [11].…”

Section: Introductionmentioning

confidence: 99%

Os Trigonum syndrome – A case report

Reddy

Prabhu

Khalid

et al. 2015

Int J of Biomed & Adv Res

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The ostrigonum is a small bone present on the posterolateral aspect of the talus. It is formed from a separate ossification center which fails to unite with the talus itself. Incidence is about 3-15%. The diagnosis can be difficult to make as symptoms and physical exam findings mimic those that occur with problems related to an accessory soleus muscle, flexor hallucislongus, posteriortibialis, or peroneal tendons, arthritis involving the posterior tibiotalar or subtalar joints, or ostrigonum syndrome. Misdiagnosis of such injuries may result in inadequate management including immediate weight bearing and prolonged symptoms

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Subtalar arthroscopy: indications, technique, and results

Cited by 78 publications

References 0 publications

Supramolecular design of self-assembling nanofibers for cartilage regeneration

Supramolecular design of self-assembling nanofibers for cartilage regeneration

Microfracture of the Knee: Are The Results Achieved In Clinical Practice Statistically Comparable to Those Presented in Controlled Studies?

Os Trigonum syndrome – A case report

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