Subthalamic stimulation differentially modulates declarative and nondeclarative memory

Hälbig, Thomas D.; Gruber, Doreen; Kopp, Ute A.; Scherer, P.; Schneider, Gerd‐Helge; Trottenberg, Thomas; Arnold, G.; Kupsch, Andreas

doi:10.1097/00001756-200403010-00031

Cited by 39 publications

(42 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the more specific effects of STN-DBS on WPT classification learning, one group found restitution of overall learning with StimON unlike StimOFF (Halbig et al 2004). A more recent study by Wilkinson and colleagues did not detect differences in the overall outcome on the WPT between PD patients with StimOFF or StimON (Wilkinson et al 2011) similar to our findings but found significantly better learning on low probability measures with StimON compared to StimOFF.…”

Section: Discussionsupporting

confidence: 86%

The subthalamic nucleus modulates the early phase of probabilistic classification learning

et al. 2014

View full text Add to dashboard Cite

Previous models proposed that the subthalamic nucleus (STN) is critical in the early phase of skill acquisition. We hypothesized that subthalamic deep brain stimulation modulates the learning curve in early classification learning. Thirteen idiopathic Parkinson's disease patients (iPD) with subthalamic deep brain stimulation (STN-DBS), 9 medically treated iPD, and 21 age-matched healthy controls were tested with a probabilistic classification task. STN-DBS patients were tested with stimulation OFF and ON, and medically treated patients with medication OFF and ON, respectively. Performance and reaction time were analyzed on the first 100 consecutive trials as early learning phase. Moreover, data were separated for low and high-probability patterns, and more differentiated strategy analyses were used. The major finding was a significant modulation of the learning curve in DBS patients with stimulation ON: although overall learning was similar to healthy controls, only the stimulation ON group showed a transient significant performance dip from trials '41-60' that rapidly recovered. Further analysis indicated that this might be paralleled by a modulation of the learning strategy, particularly on the high-probability patterns. The reaction time was unchanged during the dip. Our study supports that the STN serves as a relay in early classification learning and directs attention toward unacquainted content. The STN might play a role in balancing the short-term success against strategy optimization for improved long-term outcome. AbstractPrevious models proposed that the subthalamic nucleus (STN) is critical in the early phase of skill acquisition. We hypothesized that subthalamic deep brain stimulation modulates the learning curve in early classification learning. 13 idiopathic Parkinson's disease patients (iPD) with subthalamic deep brain stimulation (STN-DBS), 9 medically treated iPD, and 21 age-matched healthy controls were tested with a probabilistic classification task. STN-DBS patients were tested with stimulation OFF and ON, medically treated patients with medication OFF and ON, respectively. Performance and reaction time were analyzed on the first 100 consecutive trials as early learning phase. Moreover, data were separated for low and high probability patterns, and more differentiated strategy analyses were used.The major finding was a significant modulation of the learning curve in DBS patients with stimulation ON: although overall learning was similar to healthy controls, only the stimulation ON group showed a transient significant performance dip from trials '41-60' that rapidly recovered. Further analysis indicated that this might be paralleled by a modulation of the learning strategy, particularly on the high probability patterns. The reaction time was unchanged during the dip. Our study supports that the STN serves as a relay in early classification learning and directs attention towards unacquainted content.The STN might play a role in balancing the short-term success against strategy optimi...

show abstract

Section: Discussionsupporting

confidence: 86%

The subthalamic nucleus modulates the early phase of probabilistic classification learning

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Others have reported a decline in declarative memory performance after STN DBS (Faglioni et al, 1997;Halbig et al, 2004). For example, Alegret et al (2001) reported a postoperative decrease in verbal learning ability, using the Rey Auditory Verbal Learning Test, although no change was noted in the immediate condition.…”

Section: Memorymentioning

confidence: 97%

“…Thus, a review of the memory changes following STN DBS surgery is potentially confounded by the language effects noted above. Nevertheless, two studies reported memory improvements in PD patients following bilateral STN DBS (Halbig et al, 2004;Hilker et al, 2004). Halbig et al distinguished between declarative and non-declarative memory and found differential effects of DBS surgery (Halbig et al, 2004).…”

Section: Memorymentioning

confidence: 99%

“…Nevertheless, two studies reported memory improvements in PD patients following bilateral STN DBS (Halbig et al, 2004;Hilker et al, 2004). Halbig et al distinguished between declarative and non-declarative memory and found differential effects of DBS surgery (Halbig et al, 2004). Although language impairments have been observed in PD, PD is characterized by a degeneration of dopaminergic neurons, which animal studies have shown modulate synaptic strength during non-declarative memory (Schultz, 1982;Setlow and McGaugh, 2000).…”

Section: Memorymentioning

confidence: 99%

“…Multiple studies demonstrated enhancement of psychomotor speed as evidenced by reduction in response times on simple and choice reaction time tasks (Pillon et al, 2000;Dujardin et al, 2001;Halbig et al, 2004). While many studies use the Trail Making A Test to assess selective attention and cognitive flexibility, it also measures psychomotor speed.…”

Section: Psychomotor and Processing Speedmentioning

confidence: 99%

See 2 more Smart Citations

Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's disease

Halpern

Rick

Danish

et al. 2008

Int J Geriat Psychiatry

View full text Add to dashboard Cite

show abstract

Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease

et al. 2009

View full text Add to dashboard Cite

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a treatment option for patients with Parkinson's disease (PD) in the advanced stage. Besides motor improvement, DBS of the STN may also modulate cognitive and attentional functions of the basal ganglia. In our study, 13 patients with PD and bilateral DBS of the STN were assessed with DBS switched on and off by the use of a wide range of neuropsychological tasks. This included reasoning, cognitive flexibility, phonemic and semantic word fluency, verbal and nonverbal short-term memory, learning, delayed verbal memory recall, and stimulus-response incompatibility. Special emphasis was put on basic attentional functions, in particular intrinsic and phasic alertness as well as visual search. DBS significantly improved intrinsic alertness, whereas phasic alertness and other neuropsychological domains were not affected. Additionally, the effects on intrinsic alertness were independent of motor improvements by DBS. The findings suggest that DBS modulates the fronto-parietal network of alertness.

show abstract

Subthalamic stimulation differentially modulates declarative and nondeclarative memory

Cited by 39 publications

References 22 publications

The subthalamic nucleus modulates the early phase of probabilistic classification learning

The subthalamic nucleus modulates the early phase of probabilistic classification learning

Cognition following bilateral deep brain stimulation surgery of the subthalamic nucleus for Parkinson's disease

Deep brain stimulation of the subthalamic nucleus improves intrinsic alertness in Parkinson's disease

Contact Info

Product

Resources

About