Racial/ethnic minority women in a disadvantaged urban neighborhood may experience a high rate of post-traumatic stress disorder (PTSD) and depression. This brief report examined the frequency of a PTSD diagnosis and subthreshold PTSD among 72 female participants with depressive symptoms in a mindfulness-based intervention for depression at an urban federally qualified health center (FQHC). The MINI International Neuropsychiatric Interview was used to assess PTSD diagnosis or subthreshold PTSD, and the Inventory of Depressive Symptomatology-Self-Report (IDS-SR) was used to assess depressive symptoms. We conducted a descriptive analysis of trauma experiences and explored the neighborhood context of the participants. Fifty-one percent of women self-reported that they experienced a traumatic event. Twenty-nine percent of women met PTSD diagnosis and 7% had subthreshold PTSD; women with a PTSD diagnosis or subthreshold PTSD had significantly worse depressive symptoms. Commonly reported traumas included witnessing a murder, experiencing abuse, and domestic violence. This brief report highlights the high frequency of PTSD diagnosis and subthreshold PTSD among underserved women with depressive symptoms. This may be associated with trauma events linked to residing in a disadvantaged neighborhood.