Subtle Myocardial Dysfunction and Fibrosis in Children with Rheumatic Heart Disease: Insight from 3D Echocardiography, 3D Speckle Tracking and Cardiac Magnetic Resonance Imaging

Sobhy, Rodina; Samir, Mohamed; Abdelmohsen, Gaser; Ibrahim, Hossam; Rahman, Mohamed Y. Abd El; Abdel-Rahman, Nourhan H.; Behairy, Noha; Imam, OSAMA; Hamza, Hala

doi:10.1007/s00246-018-2006-5

Cited by 5 publications

(1 citation statement)

References 21 publications

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“…In pediatric patients with latent RHD, normal heart muscle function was demonstrated with conventional methods; a new technique, 3D strain echocardiography, found normal strain values during the latent stage supporting our study. 24 …”

Section: Discussionmentioning

confidence: 99%

Assessment of Myocardial Mechanics in Acute Rheumatic Fever Using Speckle-Tracking Echocardiography

et al. 2023

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Background: This study aims to evaluate the role of speckle-tracking echocardiography to identify myocardial deformation in acute rheumatic fever. Methods: Twenty-seven patients and 27 healthy children were prospectively evaluated. The patient group was divided into 2 subgroups based on echocardiographic findings, with or without carditis. The left ventricular global longitudinal strain and strain rate, left ventricular global circumferential strain and strain rate, and right ventricular global longitudinal strain and strain rate were assessed by speckle-tracking echocardiography. Results: In the acute phase of the disease, all values except the right ventricular global longitudinal strain were found to be significantly below the control group in the patient cohort. No significant difference was found between the patients grouped as carditis and non-carditis in the acute period. Comparison of the acute period with the post-treatment period revealed a significant increase in all strain values of the patients with carditis and significant increases observed in all values except left ventricular global longitudinal strain rate, left ventricular global circumferential strain rate, and right ventricular global longitudinal strain rate values in patients without carditis. Apart from the right ventricular global longitudinal strain rate, which was significantly lower in the non-carditis group compared to the control group, there was no significant difference in strain values between the patient and control groups following treatment. Conclusion: In the present study, we found that all patients, including patients in whom no valvular involvement was detected by echocardiography in the acute phase of acute rheumatic fever, had a lower right and left ventricular strain and strain rate measurements and that these findings improved after treatment, suggesting that strain echocardiography may be a helpful diagnostic method, especially in patients without valvular involvement.

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Section: Discussionmentioning

confidence: 99%

Assessment of Myocardial Mechanics in Acute Rheumatic Fever Using Speckle-Tracking Echocardiography

et al. 2023

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Impact of mitral regurgitation on left ventricular remodeling and function in children with rheumatic heart disease

Tarca

Causer

Maslin

et al. 2022

Int J Cardiovasc Imaging

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MicroR-26b Targets High Mobility Group, AT-hook 2 to Ameliorate Myocardial Infarction-induced Fibrosis by Suppression of Cardiac Fibroblasts Activation

Chen¹,

Ding²,

Li³

et al. 2020

CNR

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Background: Myocardial fibrosis (MF) is an important physiological change after myocardial infarction (MI). MicroRNA-26b (MiR-26b) has a certain inhibitory effect on pulmonary fibrosis. However, the role of miR-26b in MI-induced MF rats and underlying molecular mechanisms remain unknown. Material and methods: Forty male Sprague Dawley (SD) rats weighing 200-250g were divided into four groups (n=10): Sham group, MF group, MF + negative control (NC) agomir group and MF+miR-26b agomir group. Cardiac fibroblasts were isolated from cardiac tissue. Fibrosis levels were detected by MASSON staining, while expression of related genes was detected by RT-qPCR, Western blotting and Immunohistochemistry, respectively. TargetScan and dual luciferase reporter assay were utilized to predict the relationship between miR-26b and high mobility group, AT-hook 2 (HMGA2). Results: Study found expression of miR-26b was down-regulated in myocardium of MF rats (p < 0.01). miR-26b overexpression in vitro significantly reduced survival rate of cardiac fibroblasts and inhibited expression of fibrillar-associated protein (α-SMA alpha-smooth muscle actin (α-SMA) and collagen I) (p < 0.01). TargetScan indicated that HMGA2 was one of the target genes of miR-26b, dual luciferase reporter assay further confirmed the targeted regulatory relationship (p < 0.01). Moreover, miR-26b overexpression significantly reduced the expression of HMGA2 (p < 0.01). Notably, HMGA2 overexpression reversed the inhibitory effect of miR-26b overexpression on cardiac fibroblast viability and the expression of α-SMA and collagen I (p < 0.01). Animal experiments further indicated that miR-26b overexpression inhibited MI-induced rat MF by inhibiting the expression of HMGA2 (p <0.05, p < 0.01). Conclusion: In short, these findings indicate miR-26b targets HMGA2 to ameliorate MI-induced fibrosis by suppression cardiac fibroblasts activation.

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Subtle Myocardial Dysfunction and Fibrosis in Children with Rheumatic Heart Disease: Insight from 3D Echocardiography, 3D Speckle Tracking and Cardiac Magnetic Resonance Imaging

Cited by 5 publications

References 21 publications

Assessment of Myocardial Mechanics in Acute Rheumatic Fever Using Speckle-Tracking Echocardiography

Assessment of Myocardial Mechanics in Acute Rheumatic Fever Using Speckle-Tracking Echocardiography

Impact of mitral regurgitation on left ventricular remodeling and function in children with rheumatic heart disease

MicroR-26b Targets High Mobility Group, AT-hook 2 to Ameliorate Myocardial Infarction-induced Fibrosis by Suppression of Cardiac Fibroblasts Activation

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