Subungual Melanoma

Littleton, Travis W.; Murray, Peter M.; Baratz, Mark E.

doi:10.1016/j.ocl.2019.03.003

Cited by 23 publications

(43 citation statements)

References 24 publications

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“…These lines are irregular in colour, thickness, spacing and parallelism. Occasionally, an only‐dermoscopically visible periungual pigmentation (also known as the micro‐Hutchinson sign) is seen on the proximal nail‐fold skin (Littleton, Murray, & Baratz, 2019). More advanced stages of pigmented nail unit melanoma may be dermoscopically characterized by granulation, scar‐like depigmentation, blue‐black structureless areas, blood spots, prominent periungual pigmentation, atypical vascular areas, erosion of the nail plate or ulceration of the nail bed.…”

Section: Diagnosismentioning

confidence: 99%

Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease

Basurto-Lozada

Molina-Aguilar

Castañeda-García

et al. 2020

Pigment Cell Melanoma Res

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Section: Diagnosismentioning

confidence: 99%

Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease

Basurto-Lozada

Molina-Aguilar

Castañeda-García

et al. 2020

Pigment Cell Melanoma Res

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“…The following clinicopathological parameters were analyzed: age at the first diagnosis, sex, status of SLN biopsy, Breslow thickness (segregated into three groups with cut-off points of 1 mm and 4 mm), pathologic stage, ulceration, histopathological subtype (SSM, LMM, NM, ALM). We have chosen 5-year and 10-year OS as representative cut-offs because most of the analysis in the literature includes 5-year and 10-year OS [7,8,[11][12][13]15,19…”

Section: Clinical Data: Patient Selection and Data Acquisitionmentioning

confidence: 99%

“…The most common locations are the great toe and thumb [11][12][13][14][15]17,18]. The five-year overall survival (OS) of patients with SUM is generally poor (range 18-60%) in part because of its aggressiveness and delayed diagnosis [8,[11][12][13]15,19]. Misdiagnosed SUM cases are mainly recognized as striate melanonychia or onychomycosis, and therefore they are commonly diagnosed as an advanced disease [12].…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians

Borkowska

Szumera‐Ciećkiewicz

Spałek

et al. 2020

JCM

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Background: Cutaneous melanomas located on the acral part of extremities (hand and foot melanoma; HFM) comprise a rare group within all melanomas in Caucasians. HFM is associated with a poor prognosis. We aimed to evaluate clinicopathological features, long-term outcomes, and prognostic factors in primary HFM in Caucasians. Methods: Medical records of all consecutive patients treated between 1997 and 2014 were revised. Patients were diagnosed with primary cutaneous melanoma at I-II clinical stage, and sentinel lymph node biopsy was conducted. The analysis was performed to define the clinicopathological factors influencing outcomes in the HFM and subungual cohort. Among 2537 consecutive patients diagnosed with primary cutaneous melanoma, 247 cases of HFM (9.7%) were found, with a median follow-up time of 7.8 years. Results: Median primary tumor Breslow thickness in subungual melanomas and HFMs was 4.0 mm and 3.3 mm, respectively, significantly higher than in the entire population (median 2.2 mm; p < 0.01). In the HFM group, 37.6% of tumors were ulcerated. Metastases to sentinel lymph node (SLN) were found in 28.3% of HFMs. The 10-year overall survival rate in the HFM group and subungual melanomas was 48.1% and 49.3%, respectively, compared to 63.0% in non-HFM melanomas. Conclusions: Our results confirm that patients with HFMs display worse overall survival compared to the entire melanoma population, with male gender and positive SLN biopsy status acting as independent negative prognostic factors.

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“…It has been determined that the most crucial factor determining poor survival in these patients is due to diagnostic delay. In studies with a large number of patients, 5-year survival for SUM ranges from 25% to 91% (1,4,6); It is emphasized that the most important factor in survival is early diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…Subungual melanoma (SUM) is a subtype of melanoma that arises from the nail matrix and commonly affects other areas of the nail unit (1,2). The disease may clinically mimic more common and benign health conditions, such as infections and haematoma.…”

Section: Introductionmentioning

confidence: 99%

Subungual Melanom Tanısında Gecikme: Bir Olgu Sunumu

Karataş¹,

Fidan²

2021

Osmangazi̇ Journal of Medicine

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Subungual melanoma is a rare subtype of melanoma. Subungual melanoma usually presents as a discoloration of the nail, nail splitting, or nail bed bleeding and may easily be misdiagnosed as onychomycosis or bacterial infection. Furthermore, secondary infections are possible, which could lead to late diagnosis. For this reason, most subungual melanomas are diagnosed in advanced stages and are associated with a poor prognosis. We present the case of a 90-year-old man with a 6-year history of black discoloration in the left big toe and a 1-year history of coexisting purulent discharge, with a delayed diagnosis of subungual melanoma.

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Subungual Melanoma

Cited by 23 publications

References 24 publications

Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease

Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease

Clinicopathological Features and Prognostic Factors of Primary Acral Melanomas in Caucasians

Subungual Melanom Tanısında Gecikme: Bir Olgu Sunumu

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