Subungual onychomycosis due to Aspergillus niger mimicking a glomus tumor: A case report

Lam

et al. 2020

IAD

Background : Onychomycosis is a common fungal infection of the nail. Objective: The study aimed to provide an update on the evaluation, diagnosis, and treatment of onychomycosis. Methods: A PubMed search was completed in Clinical Queries using the key term “onychomycosis”. The search was conducted in May 2019. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews published within the past 20 years. The search was restricted to English literature. Patents were searched using the key term “onychomycosis” in www.freepatentsonline.com. Results : Onychomycosis is a fungal infection of the nail unit. Approximately 90% of toenail and 75% of fingernail onychomycosis are caused by dermatophytes, notably Trichophyton mentagrophytes and Trichophyton rubrum. Clinical manifestations include discoloration of the nail, subungual hyperkeratosis, onycholysis, and onychauxis. The diagnosis can be confirmed by direct microscopic examination with a potassium hydroxide wet-mount preparation, histopathologic examination of the trimmed affected nail plate with a periodic-acid-Schiff stain, fungal culture, or polymerase chain reaction assays. Laboratory confirmation of onychomycosis before beginning a treatment regimen should be considered. Currently, oral terbinafine is the treatment of choice, followed by oral itraconazole. In general, topical monotherapy can be considered for mild to moderate onychomycosis and is a therapeutic option when oral antifungal agents are contraindicated or cannot be tolerated. Recent patents related to the management of onychomycosis are also discussed. Conclusion: Oral antifungal therapies are effective, but significant adverse effects limit their use. Although topical antifungal therapies have minimal adverse events, they are less effective than oral antifungal therapies, due to poor nail penetration. Therefore, there is a need for exploring more effective and/or alternative treatment modalities for the treatment of onychomycosis which are safer and more effective.

Section: Differential Diagnosismentioning

confidence: 99%

Onychomycosis: An Updated Review

Lam

et al. 2020

IAD

“…The most common cause of melanonychia are dematiaceous, melanin-producing molds, Scytalidium dimidiatum and Alternaria sp [145,146]. Moreover, subungual onychomycosis due to Aspergillus niger can mimic a glomus tumor [150].…”

Section: Atypical Onychomycosismentioning

confidence: 99%

Atypical and Unpredictable Superficial Mycosis Presentations: A Narrative Review

Belmokhtar,

Djaroud,

Matmour

et al. 2024

Preprint

While typically exhibiting characteristic features, fungal infections can sometimes present in an unusual context, having improbable localization (eyelid, face, joint), mimicking other skin diseases such as eczema, psoriasis, or mycosis fungoides, and appearing with unexpected color, shape, or distribution. The emergence of such a challenging clinical pictures is attributed to complex interplay of host characteristics (hygiene, aging population), environment (climate change), advances in medical procedures, and agent factors (fungal resistance, species emergence). We aim to provide a better understanding of unusual epidemiological contexts and atypical manifestations of fungal superficial diseases, knowing that there is no pre-established clinical guide for these conditions.

“…[156,157]. Moreover, subungual onychomycosis due to Aspergillus niger can mimic a glomus tumor [162].…”

Section: Atypical Onychomycosismentioning

confidence: 99%

“…Aspergillus niger [157] Onychodystrophy Nail discoloration [160] Onycholysis Greenish-black discolorations Candida parapsilosis [167] Subungual onychomycosis Mimicking a glomus tumor Aspergillus niger [162] Onychodystrophy All fingernails and toenails involved Cladosporium sp.…”

Section: Superficial Coloration Periungual Inflammation Proximal Nailmentioning

confidence: 99%

Atypical and Unpredictable Superficial Mycosis Presentations: A Narrative Review

Belmokhtar,

Djaroud,

Matmour

et al. 2024

JoF

While typically exhibiting characteristic features, fungal infections can sometimes present in an unusual context, having improbable localization (eyelid, face, or joint); mimicking other skin diseases such as eczema, psoriasis, or mycosis fungoides; and appearing with unexpected color, shape, or distribution. The emergence of such a challenging clinical picture is attributed to the complex interplay of host characteristics (hygiene and aging population), environment (climate change), advances in medical procedures, and agent factors (fungal resistance and species emergence). We aim to provide a better understanding of unusual epidemiological contexts and atypical manifestations of fungal superficial diseases, knowing that there is no pre-established clinical guide for these conditions. Thus, a literature examination was performed to provide a comprehensive analysis on rare and atypical superficial mycosis as well as an update on certain fungal clinical manifestations and their significance. The research and standard data extraction were performed using PubMed, Medline, Scopus, and EMBASE databases, and a total of 222 articles were identified. This review covers published research findings for the past six months.