Subunit structure of 27 S thyroid iodoprotein.

Tarutani, Osamu; Kondo, Toshihiko; Smith, Daniel J.; Shulman, Sidney

doi:10.1507/endocrj1954.23.305

Cited by 3 publications

(1 citation statement)

References 7 publications

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“…10-50 iodine atoms per molecule thyroglobulin) (Nunez & Pommier 1982). Pig thyroglobulin contains up to 6% (~8 3 iodine atoms per molecule thyroglobulin) (Tarutani et al 1976, Marriq et al 1980, Rentsch et al 1981. Normal values for human thyroglobulin are between 0T5% and 0-5% (i.e.…”

Section: Normal Valuesmentioning

confidence: 99%

Low intrathyroidal iodine concentration in non-endemic human goitres: a consequence rather than a cause of autonomous goitre growth

Aeschimann

Buergi²,

Wagner³

et al. 1994

Journal of Endocrinology

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Iodine may have an inhibitory and, in some circumstances, a stimulatory effect on thyroid follicular cell growth. Exogenous iodine deficiency causes the growth of endemic goitres and it has been claimed that low intrathyroidal iodine stores stimulate growth. On the other hand, the role of iodine, if any, in regulating the growth of human nodular goitres exposed to an ample supply of iodine has not been studied systematically. Very few data on intrathyroidal iodine concentration in this type of goitre are available. In the present work we have investigated total iodine content in 24 samples from 11 clinically and histomorphologically well-defined fast and autonomously growing human nodular goitres from a non-endemic area. Iodine was fractionated into thyroglobulin-iodine and non-thyroglobulin-iodine. The regional distribution of intrathyroidal iodo-compounds was also assessed in three goitres. Total iodine concentration, as well as its sub-fractions, i.e. thyroglobulin-iodine and non-thyroglobulin-iodine, were significantly lower than in normal thyroids. Furthermore, there was large inter- and intraindividual heterogeneity of all iodo-compounds as well as of thyroglobulin. Total iodine concentration varied by a factor of almost 40 between different goitre samples and by a factor of 20 between samples taken from the same goitre. Total non-thyroglobulin-iodine, the only fraction comprising possible cell growth-regulating iodo-compounds, varied by a factor of> 60 between different goitres and by a factor of > 6 between different samples of the same goitre. The low iodine concentration in all our goitre samples did not differ from values reported in the literature for endemic iodine-deficient goitres. Since all goitres studied here were actively growing while exposed to an ample supply of iodine, iodine shortage cannot be a primary and causal factor for the growth of this type of sporadic goitre. Rather, the low concentration and the large inter- and intraindividual heterogeneity of all iodo-compounds appear to be secondary incidental events well explained by the recently developed concept of autonomous thyroid growth.

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Section: Normal Valuesmentioning

confidence: 99%