Success and risks of pregnancy after breast cancer

Pregnancy rate, maternal and neonatal outcomes among breast cancer survivors: A systematic review

“…A total of 27 studies out of 29 included studies reported maternal outcomes of pregnancy among BC survivors (Abel et al, 2021; Assi et al, 2020; Blakely et al, 2004; Córdoba et al, 2012; Dalberg et al, 2006; Dieci et al, 2019; Dillon et al, 2013; Gelber et al, 2001; Ives et al, 2007; Jacob et al, 2017; Kaidar‐Person et al, 2022; Kopeika et al, 2019; Kranick et al, 2010; Kroman et al, 1997, 2008; Labrosse et al, 2021; Lambertini, Ameye, et al, 2020; Lee et al, 2020; Leproux et al, 2021; Mangiardi‐Veltin et al, 2022; Oktay et al, 2015; Partridge et al, 2008; Poorvu et al, 2021; Rippy et al, 2009; Sutton et al, 1990; Velentgas et al, 1999). These outcomes included ectopic pregnancy (Dillon et al, 2013; Kranick et al, 2010; Labrosse et al, 2021; Mangiardi‐Veltin et al, 2022; Velentgas et al, 1999), induced abortion (Dillon et al, 2013; Kranick et al, 2010; Kroman et al, 1997, 2008; Lambertini, Kroman, et al, 2020; Rippy et al, 2009; Velentgas et al, 1999), gestational diabetes mellitus (GDM; Abel et al, 2021; Labrosse et al, 2021; Mangiardi‐Veltin et al, 2022), pre‐eclampsia (Labrosse et al, 2021; Mangiardi‐Veltin et al, 2022) and eclampsia (Kaidar‐Person et al, 2022), and metastatic recurrence of BC (Labrosse et al, 2021).…”

“…Of the 29 included studies, 12 studies were conducted in the United States (USA; Abel et al, 2021 ; Black et al, 2017 ; Blakely et al, 2004 ; Dillon et al, 2013 ; Gelber et al, 2001 ; Kranick et al, 2010 ; Mueller et al, 2003 ; Oktay et al, 2015 ; Partridge et al, 2008 ; Poorvu et al, 2021 ; Sutton et al, 1990 ; Velentgas et al, 1999 ), three studies was performed in France (Labrosse et al, 2021 ; Leproux et al, 2021 ; Mangiardi‐Veltin et al, 2022 ), two studies were conducted in Italy (Dieci et al, 2019 ; Lambertini, Ameye, et al, 2020 ), two studies in Denmark (Kroman et al, 1997 , 2008 ), two studies in the United Kingdom (UK; Kopeika et al, 2019 ; Rippy et al, 2009 ), one study was in Germany (Jacob et al, 2017 ), one study in Korea (Lee et al, 2020 ), one study in Spain (Córdoba et al, 2012 ), one study in Sweden (Dalberg et al, 2006 ), one study in Australia (Ives et al, 2007 ), one study in Finland (Sankila et al, 1994 ), one study in Israel (Kaidar‐Person et al, 2022 ) and one study was carried out in Lebanon (Assi et al, 2020 ). The included studies were published between “1990 and 2022” regarding the publication year.…”

“…The included studies were published between “1990 and 2022” regarding the publication year. Of the 29 included studies, 13 studies were prospective cohorts or prospective multicenter or population‐based cohort (Abel et al, 2021 ; Blakely et al, 2004 ; Dalberg et al, 2006 ; Dillon et al, 2013 ; Kaidar‐Person et al, 2022 ; Kroman et al, 2008 ; Lambertini, Ameye, et al, 2020 ; Lee et al, 2020 ; Mangiardi‐Veltin et al, 2022 ; Oktay et al, 2015 ; Poorvu et al, 2021 ; Sutton et al, 1990 ; Velentgas et al, 1999 ), 14 studies were retrospective cohort or retrospective population‐based cohort studies (Assi et al, 2020 ; Black et al, 2017 ; Córdoba et al, 2012 ; Dieci et al, 2019 ; Gelber et al, 2001 ; Jacob et al, 2017 ; Kopeika et al, 2019 ; Kranick et al, 2010 ; Kroman et al, 1997 ; Labrosse et al, 2021 ; Leproux et al, 2021 ; Mueller et al, 2003 ; Rippy et al, 2009 ; Sankila et al, 1994 ), and two studies were cross‐sectional retrospective survey or population‐based descriptive studies (Ives et al, 2007 ; Partridge et al, 2008 ). The sample size from 29 assessed studies was from 39 to 2,325,229 women.…”

“…According to the results of 24 of 29 included studies, the shortened mean ± SD time between treatments and pregnancy occurrence among BC survivors was 3.7 months. The primary and secondary outcomes measured in most of the included studies were the pregnancy rate or live birth after BC (Dillon et al, 2013 ; Ives et al, 2007 ; Labrosse et al, 2021 ; Lambertini, Ameye, et al, 2020 ; Leproux et al, 2021 ; Sutton et al, 1990 ) or pregnancy attempt or post BC diagnosis pregnancies (Abel et al, 2021 ; Kopeika et al, 2019 ; Poorvu et al, 2021 ), fertility preservation procedures or fertility discussion regarding the effect of BC on future pregnancy among BC survivors (Assi et al, 2020 ; Mangiardi‐Veltin et al, 2022 ; Rippy et al, 2009 ), the pregnancy or birth outcomes or complications among survived women with BC (Dalberg et al, 2006 ; Dieci et al, 2019 ; Jacob et al, 2017 ; Kaidar‐Person et al, 2022 ; Labrosse et al, 2021 ; Oktay et al, 2015 ; Partridge et al, 2008 ), the association between BC and birth outcomes (Black et al, 2017 ), the risks of recurrence and mortality due to pregnancy (Blakely et al, 2004 ; Kroman et al, 1997 ; Lee et al, 2020 ; Velentgas et al, 1999 ) or BC outcomes or prognosis due to pregnancy among survivors (Córdoba et al, 2012 ; Gelber et al, 2001 ; Kranick et al, 2010 ; Kroman et al, 2008 ; Sutton et al, 1990 ) and overall survival rate among BC survivors (Lambertini, Ameye, et al, 2020 ; Leproux et al, 2021 ; Mueller et al, 2003 ; Sankila et al, 1994 ; Table 2 ).…”

“…Studies conducted among BC survivors regarding the pregnancy complications, such as maternal and neonatal outcomes, showed contradicting results. Although some studies did not report higher maternal (Black et al, 2017 ; Mueller et al, 2003 ) and neonatal (Assi et al, 2020 ; Leproux et al, 2021 ) complications among BC survivors, in some population‐based cohort studies, an increased risk of adverse delivery complications such as caesarean section, low birth weight (LBW), very preterm birth (PTB), and neonate small for gestational age (SGA) was reported compared with the healthy women (Black et al, 2017 ; Mogos et al, 2013 ). Reproductive‐aged BC survivors are considered a high‐risk population, and their pregnancy health should be noticed by healthcare providers, especially midwives, and gynaecologists (Bien et al, 2014 ).…”