Higher education can be challenging for many students, but for those with disabilities, it presents additional hurdles. Oftentimes, students with disabilities must navigate both their academic responsibilities and the unique challenges posed by their disabilities. This chapter provides a comprehensive overview of the most frequently reported challenges and barriers to academic success for students with disabilities in higher education. The chapter focuses on several key issues, including but not limited to societal attitudes surrounding disability and provision of academic accommodation, students' willingness to disclose their disabilities in their institutes, and difficulties with social integration. Each of these challenges is explored in depth, highlighting the critical areas where students with disabilities may require additional assistance. Furthermore, the chapter discusses the importance of acknowledging and embracing diversity in higher education as it results in promoting knowledge, understanding, and social justice for both students with and without disabilities.