This study aims to identify and analyze the success factors of small and medium-sized enterprises (SMEs) following the lines of dynamic capabilities and resources-based views. Methodology: To achieve this objective, the multiple case study method was followed, where 20 SMEs/cases in Iran were selected. For this purpose, the statistical population of the research is the managers, experts and experts of small and medium-sized enterprises. For determining the sample size, a targeted sampling method has been used. The reliability of the questionnaire was also confirmed by Cronbach's Alpha (α = 0.971) and its validity was confirmed by experts and experts. Finally, ISM technique used to analyze information. Findings: From a content analysis of the interviews conducted to the ownermanagers of these SMEs, the most important success factors identified were: 1) Business environment, 2) Capital availability, 3) Business support, 4) Leadership and Management, 5) Business characteristics, 6) Individual factors, 7) Government Support, 8) Infrastructure, 9) Human Resource Management and 10) Networks/Partnerships. Originality/Value: Entrepreneurship and SMEs are integral to economic and social development and regeneration. It is recognized that, SMEs are the engine of economic growth through employment generation, contribution to GDP, technological innovations, and other aspects of economic and social development.