Success of Biodentine and Ferric Sulfate as Pulpotomy Materials in Primary Molars: A Retrospective Study

Brar, Kelsey A; Kratunova, Evelina; Avenetti, David; Fonseca, Marcio A da; Marion, Ian; Alapati, Satish B.

doi:10.17796/1053-4625-45.1.5

Cited by 3 publications

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“…The application of biocompatible materials on the root pulp tissue can preserve vitality and stimulate the neoformation of mineralized tissue [2,3]. In the present study, we chose to compare MTA and BD since we can observe in the literature that they have similar clinical successes in approximately 100% of the cases [27,[30][31][32][33][34][35]. Recent studies demonstrate the clinical and radiographic success of teeth that underwent pulpotomy with MTA or BD [36,37].…”

Section: Discussionmentioning

confidence: 99%

Randomized Clinical Study of the Use of MTA and Biodentine™ for Pulpotomy in Primary Teeth

Hidalgo,

Almeida-Junior,

Politi

et al. 2023

Pesqui. Bras. Odontopediatria Clín. Integr.

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Objective: To verify, through clinical and radiographic evaluations, the in vivo response of the dentin-pulpal complex of human primary teeth after pulpotomy with MTA and Biodentine™ in a follow-up period of 3, 6, and 12 months. Material and Methods: Thirty teeth were divided into MTA pulpotomy (n = 15) and Biodentine™ pulpotomy (n = 15) from children between 5 and 9 years of age, a randomized clinical trial with simple random sampling. The materials were inserted into the cavity after opening and removing the coronary pulp tissue. The cavity base consisted of glass ionomer cement and light-cured composite resin restoration. Clinical and radiographic analyses were performed after 3, 6, and 12 months. Statistical analysis by Fisher's exact test for dichotomous data at a 5% significance level was utilized. Results: Both materials caused color change after 12 months. However, MTA showed a higher percentage than Biodentine™ (p<0.0001). Pain was detected only with Biodentine™ at six months and mobility at 12 months (p=0.0013). Radiographically, after 12 months, periapical lesions, interradicular lesions, and internal resorption were evidenced in 13% of the cases for Biodentine™-treated teeth (p<0.0013). MTA induced pulp calcification in 13% of cases, unlike Biodentine™ (p<0.0013). Conclusion: Biodentine TM and MTA are suitable for clinical use in pulpotomy treatment, yet both materials lead to tooth discoloration.

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Section: Discussionmentioning

confidence: 99%

Randomized Clinical Study of the Use of MTA and Biodentine™ for Pulpotomy in Primary Teeth

Hidalgo,

Almeida-Junior,

Politi

et al. 2023

Pesqui. Bras. Odontopediatria Clín. Integr.

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“…Reference [49] selected 71 primary molars with deep carious lesions, they performed pulpotomy with FS and they found that the overall success rate at 24 months follow up was 91.5%. Reference [50] divided 102 primary molars in two groups and they performed in the group of 79 teeth pulpotomy with FS and the results showed that the clinical and radiographic success rates of this group were 84% and 70% respectively. Also, worth mentioning is the pulpal response to the use of the FS as a pulpotomy agent from a histological sight.…”

Section: Ferric Sulfatementioning

confidence: 99%

Pulp Dressing Agents Used in Primary Teeth: A Review of the Literature

Boulioni

Arhakis

2022

EJDENT

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Background: Pulpotomy is a technique of vital pulp therapy which can be performed in a primary tooth with pulp exposure due to caries or trauma when there is no clinical or radiographic sign of irreversible pulpitis or necrosis. Since today many different medicaments and techniques have been researched as pulpotomy agents and studies have shown the effectiveness but also the limitations of them. Aim: The aim of this literature review is to overview the medicaments which were used in the past for pulpotomy in primary teeth, but also to evaluate the techniques and medicaments from the present and the future. Results: Formocresol was the first-choice material for many decades, but its use has been limited due to potential mutogenetic and carcinogenetic effects in humans. In addition, glutaraldehyde is no longer used as a material for pulpotomy due to its toxicity. Mineral trioxide aggregate (MTA) seems to have better or comparable success rates as the old gold standard – formocresol, while other materials have high effectiveness. Calcium hydroxide was related to lower success rate and due to adverse effects as the internal root resorption is no longer recommended. Electrosurgery and laser are alternative techniques, while collagen and enamel matrix derivative (EMD) have been researched the last years and also studies about the bone morphogenetic proteins (BMPs) presented promising results. Also, other medicaments, which have been evaluated as pulp dressing materials, are included in this review and they seem to lead to acceptable results. Conclusions: MTA seems to be the new gold-standard for pulpotomy, while also other medicaments as ferric sulfate, sodium hypochloride, Portland cement, Biodentine can lead to comparable results. Electrosurgery and laser pulpotomy are alternative and non-pharmacological techniques with good success rates, while also other alternative materials seem to have promising results, but further research is needed.

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SPAG5 Promotes the Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transformation of Colorectal Cancer Cells by Activating the PI3K/AKT Signaling Pathway

Zhang¹,

Zhang²,

Wu³

et al. 2023

Chinese Journal of Physiology

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Colorectal cancer (CRC) is a cancer that occurs in the rectum or colon with a high incidence. Sperm-associated antigen 5 (SPAG5), a gene that regulates cell division, has been observed highly expressed in a variety of cancers, but its role in CRC is unclear. This study aimed to investigate the regulatory role of SPAG5 in CRC. The expression of SPAG5 in multiple cancers and normal tissues was predicted by The Cancer Genome Atlas and Tumor Immune Estimation Resource, and the expression of SPAG5 in human normal intestinal epithelial cells NCM460 and human CRC cell lines Caco2, HT29, SW480, and LOVO was verified by western blotting (WB). The effects of silencing SPAG5 on cell viability, proliferation, and apoptosis were then investigated by cell counting kit-8, WB, and flow cytometry. The effects of silencing SPAG5 on cell migration and invasion were investigated by scratch assay and transwell assay. Finally, the phosphorylation levels of phosphoinositide 3-kinase (PI3K) and AKT in cells were detected by WB. The results showed that SPAG5 was highly expressed in CRC and was verified by WB. Silencing of SPAG5 inhibited cell viability and proliferation and increased the cell apoptosis rate. Furthermore, both cell invasion and migration abilities were suppressed by the low expression of SPAG5. Finally, WB results found that the phosphorylation levels of PI3K and AKT were reduced after SPAG5 silencing. In summary, the results showed that SPAG5 can promote the proliferation and invasion of CRC cells by targeting the PI3K/AKT signaling pathway.

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Success of Biodentine and Ferric Sulfate as Pulpotomy Materials in Primary Molars: A Retrospective Study

Cited by 3 publications

References 0 publications

Randomized Clinical Study of the Use of MTA and Biodentine™ for Pulpotomy in Primary Teeth

Randomized Clinical Study of the Use of MTA and Biodentine™ for Pulpotomy in Primary Teeth

Pulp Dressing Agents Used in Primary Teeth: A Review of the Literature

SPAG5 Promotes the Proliferation, Migration, Invasion, and Epithelial-Mesenchymal Transformation of Colorectal Cancer Cells by Activating the PI3K/AKT Signaling Pathway

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