Success of Repeat Detrusor Injections of Botulinum A Toxin in Patients with Severe Neurogenic Detrusor Overactivity and Incontinence

Efficacy and duration of response to botulinum neurotoxin A (onabotulinumA) as a treatment for detrusor overactivity in women

“…Although, Rechberger et al reported data for a relatively large female population with idiopathic DO, they report only inter-treatment intervals for five treatments [11]. Previous studies are summarized in Table 3 [11][12][13][14][15][16][17]. Most of these studies evaluated up to five or six treatments, and suggest an inter-treatment interval between 6.0 and 11.1 months.…”

“…The necessity for repeat treatment and treatment failure are attributed to axonal regeneration and possible activation of antitoxin antibodies [12]. The toxin effect on the detrusor muscle fades after about 1 year [12].…”

“…The toxin effect on the detrusor muscle fades after about 1 year [12]. Therefore, patients need to be informed about the potentially temporary nature of the treatment and the possibility of requiring repeated treatments.…”

Treatment satisfaction and goal attainment with onabotulinumtoxinA in patients with incontinence due to idiopathic OAB

“…Patient satisfaction with botulinum toxin A therapy for treatment of neurogenic [15][16][17][18][19][20][21][22][23][24] and idiopathic [16,[25][26][27] OAB has been reported in the literature to be high. However, the other studies that had previously evaluated satisfaction with botulinum toxin A therapy in patients with idiopathic OAB used varying methodologies that provided a relatively less comprehensive assessment of patient satisfaction than the current study [16,[25][26][27].…”

Botulinum toxin for neurogenic bladder dysfunction

“…Botulinum toxin · Bladder · Neurogenic bladder · Bladder dysfunction · Urethra schen 6,7-13,0 Monaten [8,15,22,23,29,32].…”