The objective of this prospective clinical trial was to assess the influence of the type of prosthetic restoration as well as the degree of hard-tissue loss on 7-year clinical performance of endodontically treated teeth restored with fiber posts. Two groups (n=60) were defined depending on the type of prosthetic restoration needed: (1) single unit porcelain-fused to metal (PFM) crowns (SCs) and (2) 3-4 unit PFM fixed dental prostheses (FDPs). Within each group, samples were randomly divided into 2 subgroups (n=30) according to the amount of residual coronal tissues after abutment build-up and final preparation: (A) more than 50% of coronal residual structure, (B) equal to or less than 50% of coronal residual structure. The clinical outcome was assessed based on clinical and intra-oral radiographic examinations at the recalls after 6, 12, 24, 36, 48 and 84 months. Data were analyzed by Kaplan-Meier Log Rank test and Cox regression analysis (p<0.05). The overall 7-year survival rate of endodontically treated premolars restored with fiber post and either PFM SCs or FDPs was 69.2%. The highest 84-months survival rate was recorded in Group 1A (90%), whereas teeth in Group 2B exhibited the lowest performance (56.7% survival rate). The Log Rank test detected statistically significant differences in survival rates among the groups (p=0.048). Cox regression analysis revealed that the amount of residual coronal structure (p=0.041) and the interaction between the type of prosthetic restoration and the amount of residual coronal structure (p=0.024) were statistically