Successes of Modelling Parkinson Disease in Drosophila

Staveley, Brian E.

doi:10.5772/18844

Mechanisms in Parkinson's Disease - Models and Treatments 2012

DOI: 10.5772/18844

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Successes of Modelling Parkinson Disease in Drosophila

Brian E. Staveley¹

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2016

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Inhibition of foxo and minibrain in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in Drosophila melanogaster

Chavoshi

Staveley

2016

APD

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Symptoms of Parkinson Disease (PD), the second most common neurodegenerative disease, emerge due to degeneration of dopaminergic neurons. Recently, a genome wide study revealed a role for a foxo transcription factor in PD. In the model organism Drosophila melanogaster, we have attempted 1) to inhibit the sole Drosophila homologue of foxo through the directed expression of a stable inducible RNAi transgene and 2) to indirectly increase foxo transcription activity through the inhibition of the kinase minibrain (mnb), a foxo transcriptional inhibitor. To evaluate the lifetime consequences upon the flies, longevity assays and locomotion over time assays were conducted. The inhibition of foxo by foxo-RNAi decreases life span significantly when expressed under the control of Tyrosine Hydroxylase-Gal4 (TH-Gal4). The targeted expression of mnb-RNAi, in the dopaminergic neurons, with an expected loss of suppression of foxo transcriptional activity, results in a significant loss of climbing ability. Thus alteration of foxo activity, both by RNA-inhibition and by down-regulation of an inhibitor of foxo, minibrain, produces novel Drosophila models of Parkinson Disease.

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Inhibition of foxo and minibrain in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in Drosophila melanogaster

Chavoshi

Staveley

2016

APD

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Successes of Modelling Parkinson Disease in Drosophila

Cited by 1 publication

References 71 publications

Inhibition of <i>foxo</i> and <i>minibrain</i> in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in <i>Drosophila melanogaster</i>

Inhibition of <i>foxo</i> and <i>minibrain</i> in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in <i>Drosophila melanogaster</i>

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Successes of Modelling Parkinson Disease in Drosophila

Cited by 1 publication

References 71 publications

Inhibition of &lt;i&gt;foxo&lt;/i&gt; and &lt;i&gt;minibrain&lt;/i&gt; in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in &lt;i&gt;Drosophila melanogaster&lt;/i&gt;

Inhibition of &lt;i&gt;foxo&lt;/i&gt; and &lt;i&gt;minibrain&lt;/i&gt; in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in &lt;i&gt;Drosophila melanogaster&lt;/i&gt;

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Inhibition of <i>foxo</i> and <i>minibrain</i> in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in <i>Drosophila melanogaster</i>

Inhibition of <i>foxo</i> and <i>minibrain</i> in Dopaminergic Neurons Can Model Aspects of Parkinson Disease in <i>Drosophila melanogaster</i>