Successful 24-Hour Preservation of the Canine Liver

Petrie, Clarence R.; Woods, John E.

doi:10.1001/archsurg.1973.01350210091023

Cited by 14 publications

(3 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other preoperative and postoperative management has been detailed previously. 9 Results Of the 19 dogs that underwent orthotopic liver transplantation after 48 hours of liver preservation, 6 13 dogs died within 24 hours after operation. Dogs that survived more than 3 days usually woke up within a few hours after operation and could stand up and walk in the evening, with various degrees of difficulty.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Forty-Eight-Hour Preservation of the Canine Liver

Sung

Woods

1974

Annals of Surgery

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

“…9 The chief difference in the dogs receiving livers after 48-hour preservation was that bleeding diathesis was a more serious and frequent problem.…”

Section: Daysmentioning

confidence: 99%

Forty-Eight-Hour Preservation of the Canine Liver

Sung

Woods

1974

Annals of Surgery

View full text Add to dashboard Cite

“…In practical terms an extension of safe preservation times to [12][13][14][15][16][17][18][19][20][21][22][23][24] h would transform the logistic and organizational problems, allowing semi-elective arrangements for the recipient operation during regular operating time. Similarly this sort of extension in preservation time would permit more distant organ procurement in emergency cases and allow sharing of organs between centres for urgent cases or where the local transplant centre has no appropriate recipients for a particular organ.…”

Section: Early Developments In Preservationmentioning

confidence: 99%

Review article: improved preservation of the liver for transplantation

Jamieson

1991

Aliment Pharmacol Ther

View full text Add to dashboard Cite

SUMMARY This paper reviews the development of the techniques used for liver preservation and describes their clinical use. Recent advances with the introduction of lactobionate based solutions for simple cold storage are described and illustrated by their effect on the Cambridge/King's College Hospital transplant programmes. Better preservation of the liver has simplified the logistics of the transplant procedure, improving organ usage and allowing increased sharing of livers for urgent or paediatric cases.

show abstract

Liver preservation: The past and the future

Blankensteijn

Terpstra

1991

Hepatology

View full text Add to dashboard Cite

The ultimate objective of organ preservation is unrestricted and immediate graft function after a transplant under optimal conditions in the most suitable recipient. This means that time and efficacy are the basic features of the search for the ideal preservation method. Theoretically, freezing and continuous aerobic perfusion are the only means of obtaining truly long-term preservation (from a month to years). From a clinical point of view, however, the preferred method of preserving livers for brief periods before transplantation is simple cold storage (1).Until recently, cold storage of the graft in Collins' solution provided acceptable graft function when preservation time was 8 hr or less (2). Still, in the first report of the European Liver Transplant Registry (31, reviewing 1,315 liver transplantations performed at 32 different centers from 1968 to 1987, one of the principal causes of loss of the graft (and occasionally of death of the patient) appeared to be the so-called "primary nonfunction" of the liver. In most cases this was thought to be through an injury caused by inadequate preservation. To keep the period of cold storage to a minimum, close coordination of two full surgical teams -one for the donor and one for the recipient -was necessary, and the recipient operation had to be performed as an emergency procedure, often at night. Furthermore, only a very narrow margin of safety existed in the storage time, in case of unforeseen delays or unanticipated, timeconsuming difficulty in the recipient operation.To evaluate the possibility of liver transplantation on a (semi-) elective basis, Belzer (4) looked at the clinical needs for preservation times and concluded that 12 to 18 hr was necessary for liver transplantation to be performed electively.Similar to kidney transplantation, (semi-) elective liver transplantation will yield substantial benefits: because simultaneous donor and recipient operations are not required, an unnecessary recipient laparotomy may be prevented if the donor organ appears unsuitable for transplantation. Furthermore, if laparotomy findings indicate that the recipient is unsuitable for

show abstract

Successful 24-Hour Preservation of the Canine Liver

Cited by 14 publications

References 13 publications

Forty-Eight-Hour Preservation of the Canine Liver

Forty-Eight-Hour Preservation of the Canine Liver

Review article: improved preservation of the liver for transplantation

Liver preservation: The past and the future

Contact Info

Product

Resources

About