Successful administration of carboplatin in patients with clinically documented carboplatin hypersensitivity

Clinical features and management of carboplatin-related hypersensitivity reactions in pediatric low-grade glioma

“…During desensitization, drug antigens are reintroduced in a slow and incremental fashion, allowing for full therapeutic doses to be administered. Prolonging infusion time also provides chemotherapy agent antigens to be delivered in a less concentrated fashion per unit of time, therefore decreased the antigenic exposure [5,27]. However, it is not possible to determine whether desensitization protocol has contributed to the maintenance of carboplatin chemotherapy in our study group since some of our patients were coadministered premedication along with the desensitization similar to other desensitization studies [4,14,22,28].…”

Management of Hypersensitivity to Platinum- and Taxane-Based Chemotherapy: cepo Review and Clinical Recommendations

“…In most cases, efficacy and safety results are nonexistent or minimal. The desensitization protocols for platinum drugs and taxanes discussed earlier in this article were administered to 15 or more patients 40,41,57,67,70,71 and are based on administering treatment in numerous dilutions and gradual steps. The associated success rate is nearly 100%, with no severe hypersensitivity reactions in most cases.…”

“…Other multi-step desensitization protocols of 4-13 steps have been suggested 40,[69][70][71] . Most patients completed them with few or no hypersensitivity symptoms.…”

4-step 4-h carboplatin desensitization protocol for patients with gynecological malignancies showing platinum hypersensitivity: a retrospective study

“…In several reports, patients who experienced platinumrelated HSRs were successfully desensitized to carboplatin [10][11][12][13][14][15]. However, the desensitization methods differed somewhat between these reports, although almost all were accomplished through a planned chemotherapy schedule.…”