Successful aortocoronary bypass in osteogenesis imperfecta

Abstract

Cardiovascular abnormalities are infrequently documented in osteogenesis imperfecta, one of a group of hereditary, generalized connective tissue disorders. A patient with osteogenesis imperfecta is described with mitral valve prolapse, significant coronary artery disease and a coronary artery aneurysm. The latter two cardiac defects are apparently rare in this disease. The option of surgery was carefully considered with regard to technical feasibility and potential deterioration of the graft anastomoses. Although successful aortocoronary bypass surgery had not been previously reported in osteogenesis imperfecta, this patient received such surgery with therapeutic benefit. Therefore, coronary artery vascularization should be considered as a safe and effective treatment modality for patients with osteogenesis imperfecta and coexisting coronary atherosclerosis.

Premature Atherosclerosis and Drug Eluting Stent Restenosis in an Adult with Osteogenesis Imperfecta

“…Despite the possible complications due to brittleness and friability of bones, there are several cases which had been successfully treated with aortocoronary bypass grafting and sternotomy. 6,7 A ministernotomy approach which was successfully performed for the aortic valve replacement in a patient with OI can be proposed as an alternative option. 8 Coronary dissection during coronary angiography had been developed and resulted with emergency aortic valve replacement and coronary bypass grafting in a patient with OI.…”