Successful autologous stem cell transplantation in Gaucher disease patient with multiple myeloma

Aubourg, Alexandre; Benboubker, Lotfi; Picon, Laurence; Goupille, Philippe; Maillot, F.

doi:10.1002/ajh.22028

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…Multiple myeloma (Pinkhas et al , ; Benjamin et al , ; Ruestow et al , ; Garfinkel et al , ; Kolodny et al , ; Lee, ; Miller et al , ; Shoenfeld et al , ; Gal et al , ; Shiran et al , ; Shvidel et al , ; Allen et al , ; Brady et al , ; Harder et al , ; Mateja et al , ; Zimran et al , ; de Fost et al , , ; Cheung et al , ; Grosbois et al , ; Machaczka et al , ; Taddei et al , ; Aubourg et al , ; Hawkesford et al , ; Lieblich et al , ); current report…”

Section: Resultsunclassified

“…An increased risk of several non-haematological cancers has been reported for GD patients. The increased risk of (Pinkhas et al, 1965;Benjamin et al, 1979;Ruestow et al, 1980;Garfinkel et al, 1982;Kolodny et al, 1982;Lee, 1982;Miller et al, 1982;Shoenfeld et al, 1982;Gal et al, 1988;Shiran et al, 1993;Shvidel et al, 1995;Allen et al, 1997;Brady et al, 1997;Harder et al, 2000;Mateja et al, 2000;Zimran et al, 2005;de Fost et al, 2006de Fost et al, , 2008Cheung et al, 2007;Grosbois et al, 2009;Machaczka et al, 2009;Taddei et al, 2009;Aubourg et al, 2011;Hawkesford et al, 2011;Lieblich et al, 2011); current report Amyloidosis (Dikman et al, 1978;Hanash et al, 1978;Hrebicek et al, 1996;Kaloterakis et al, 1999; N, number of patients, no conclusions on incidence of the reported malignancies can be drawn based on these data. One study (Lo et al, 2010) was excluded because it covered the same cohort reported by Taddei et al (2009 (2006), who reported two cases of HCC, resulting in a relative risk of 141Á3.…”

Section: Other Malignanciesmentioning

confidence: 99%

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Malignancies and monoclonal gammopathy in Gaucher disease; a systematic review of the literature

et al. 2013

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SummaryGaucher disease is an autosomal, recessively inherited, lysosomal storage disease, which has been associated with gammopathies and malignancies. This report represents the results of a systematic review of the literature on the prevalence of monoclonal gammopathies and malignancies in Gaucher disease. A PubMed search identified 365 studies, of which 80 reported on concomitant Gaucher disease and malignancies and/or gammopathies (15 cohort/cross sectional studies, and 65 case reports/series). Based on these studies, we conclude that compared to the general population, Gaucher patients have an increased risk of cancer in general [pooled relative risk of 1Á70 (95% confidence interval 1Á27-2Á31)], and multiple myeloma and haematological malignancies in particular (estimated risk between 25Á0 and 51Á1 and 3Á5 and 12Á7, respectively). In addition, an increased risk has been reported for hepatocellular carcinoma and renal cell carcinoma. Several factors have been hypothesized to play a role in the pathophysiology. These include: splenectomy, immune dysregulation, endoplasmic reticulum stress, genetic modifiers, altered iron metabolism and insulin resistance.

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Section: Resultsunclassified

Section: Other Malignanciesmentioning

confidence: 99%

Malignancies and monoclonal gammopathy in Gaucher disease; a systematic review of the literature

et al. 2013

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“…Subjects were categorized as being insulin resistant when HOMA-IR was equal to or more than 2.86 (above the 75th percentile for HOMAIR derived from the Third National Health and Nutrition Examination Survey) (28). Total cholesterol, LDL-C, HDL-C, and triglycerides were measured through the GCRC Core laboratory using the Beckman Synchron CX9ALX system (Beckman Coulter, Fullerton, CA) (29-31). The Harvard FFQ is a well-validated and much-studied assessment tool for measuring usual food intake over the previous year (32-34).…”

Section: Methodsmentioning

confidence: 99%

Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia

Tonorezos

Robien

Eshelman-Kent

et al. 2012

Cancer Causes Control

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Purpose Determine the relationship between diet and metabolic abnormalities among adult survivors of childhood acute lymphoblastic leukemia (ALL). Methods We surveyed 117 adult survivors of childhood ALL using the Harvard Food Frequency Questionnaire. Physical activity energy expenditure (PAEE) was measured with the SenseWear Pro2 Armband. Insulin resistance was estimated using the Homeostasis Model for Insulin Resistance (HOMA-IR). Visceral and subcutaneous adiposity were measured by abdominal CT. Adherence to a Mediterranean diet pattern was calculated using the index developed by Trichopoulou. Subjects were compared using multivariate analysis adjusted for age and gender. Results Greater adherence to a Mediterranean diet pattern was associated with lower visceral adiposity (P=0.07), subcutaneous adiposity (P<0.001), waist circumference (P=0.005), and body mass index (P=0.04). For each point higher on the Mediterranean Diet Score, the odds of having the metabolic syndrome fell by 31% (OR 0.69; 95% CI 0.50, 0.94; P = 0.019). Higher dairy intake was associated with higher HOMA-IR (P =0.014), but other individual components of the Mediterranean diet, such as low intake of meat or high intake of fruits and vegetables, were not significant. PAEE was not independently associated with metabolic outcomes, although higher PAEE was associated with lower body mass index. Conclusions Adherence to a Mediterranean diet pattern was associated with better metabolic and anthropometric parameters in this cross-sectional study of ALL survivors.

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“…Subjects were categorized as being insulin resistant when HOMA-IR was equal to or more than 2.86 (above the 75th percentile for HOMAIR derived from the Third National Health and Nutrition Examination Survey) (28). Total cholesterol, LDL-C, HDL-C, and triglycerides were measured through the GCRC Core laboratory using the Beckman Synchron CX9ALX system (Beckman Coulter, Fullerton, CA) (29)(30)(31). The Harvard FFQ is a well-validated and much-studied assessment tool for measuring usual food intake over the previous year (32)(33)(34).…”

Section: Methodsmentioning

confidence: 99%

Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia.

Tonorezos

Kent

Moskowitz

et al. 2012

JCO

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9552 Background: Survivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for obesity, insulin resistance and increased visceral adiposity. A history of cranial radiation therapy (CRT) worsens this risk. In non-cancer populations, adherence to a Mediterranean Diet has been shown to improve metabolic parameters and risk of diabetes mellitus. Whether diet may contribute to insulin resistance and increased adiposity in ALL survivors is not known. Methods: We surveyed 117 adult survivors of childhood ALL using the Harvard Food Frequency Questionnaire. Physical activity energy expenditure (PAEE) was measured with the SenseWear Pro2 Armband. Fasting blood was obtained on all subjects and insulin resistance was estimated using the Homeostasis Model for Insulin Resistance (HOMA-IR). Visceral adiposity was measured by abdominal CT. Adherence to a Mediterranean Diet pattern was calculated using the index developed by Trichopoulou. Subjects were compared using univariate analysis. Results: Subjects were majority female (56%); 25% were minority or Hispanic white. A history of CRT was present in 15 (29%) men and 25 (38%) women. Among all subjects, greater adherence to a Mediterranean diet pattern was associated with improved HOMA-IR (p=0.14), visceral adiposity (p=0.03), subcutaneous adiposity (p=0.005), waist circumference (p=0.02), and body mass index (p=0.03) (all unadjusted analyses). The effect of adherence to a Mediterranean diet on insulin resistance was especially notable in men who did not receive CRT (p=0.06). Higher dairy intake was found to worsen HOMA-IR (p=0.014), but other individual components of the Mediterranean diet, such as low intake of meat and high intake of fruits and vegetables, were not significant. Inclusion of PAEE did not alter our findings, although higher PAEE was associated with lower body mass index. Conclusions: Adherence to a Mediterranean diet pattern, especially low consumption of dairy products, may improve insulin resistance in survivors of childhood ALL. Further study is warranted.

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Successful autologous stem cell transplantation in Gaucher disease patient with multiple myeloma

Cited by 4 publications

References 12 publications

Malignancies and monoclonal gammopathy in Gaucher disease; a systematic review of the literature

Malignancies and monoclonal gammopathy in Gaucher disease; a systematic review of the literature

Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia

Contribution of diet and physical activity to metabolic parameters among survivors of childhood leukemia.

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