Successful autotransplantation of cryopreserved ovarian tissue with recovery of the ovarian function

Radwan, Paweł; Abramik, Adam; Wilczyński, Jacek R.; Radwan, Michał

doi:10.17772/gp/61981

Cited by 7 publications

(1 citation statement)

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“…The gold standard for validating follicle survival in frozen human ovarian tissue has been the in vivo ability of the follicles to survive after thawing and develop following autotransplantation into patients or xenografting into immunodeficient mice (Rosendahl et al, 2015;Radwan et al, 2016;Kristensen et al, 2018). However, these methods are costly and require high technical skills and equipment.…”

Section: Introductionmentioning

confidence: 99%

Ovarian tissue cryopreservation by vitrification: The first Vietnam experience

Lan,

Tri,

Diem

et al. 2024

Vietnam J. Biotechnol.

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Ovarian Tissue Cryopreservation (OTC) is a promising technique for reproductive preservation in women with cancer. Although this technique has been successfully applied in many Invitro Fertilization (IVF) centers worldwide, OTC has not been recently developed in Vietnam, and there are no publications of OTC. The study of OTC by vitrification at IVFMD, My Duc Hospital, was conducted from 2018 to 2023 with trial registration number NCT04666376. Ovarian tissues from each patient were divided into 3 groups: group 1, which consisted on fresh tissues as a control group; group 2, which consisted of vitrified tissues using the Ova Kit Type M (Kitazato, Japan); and group 3, which consisted of vitrified tissues using IVFMD medium. The findings showed that the rates of viable follicles and follicles with both healthy oocytes and CGs in groups 2 and 3 were significantly lower than in group 1, at [80.3% in group 1, 70% in group 2, and 65% in group 3] and [71.3% in group 1, 59.4% in group 2, and 58.3% in group 3] respectively (P < 0.05). The results aligned with previous findings due to the negative effects of cryopreservation. Moreover, it was illustrated that there was no change in the quality of tissue between the commercial medium and IVFMD’s medium in OTC.

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Section: Introductionmentioning

confidence: 99%

Ovarian tissue cryopreservation by vitrification: The first Vietnam experience

Lan,

Tri,

Diem

et al. 2024

Vietnam J. Biotechnol.

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Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort

Gellert

Pors

Kristensen

et al. 2018

J Assist Reprod Genet

245

204

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This study found no indications of sufficient numbers of malignant cells present in the ovarian tissue to cause recurrence of cancer after OTT. Further, it is unlikely that OTC affects the well-being of children born. OTC is now an established method of fertility preservation in Denmark with public reimbursement. The current data encourage that women who require gonadotoxic treatment should be offered an individual evaluation considering fertility preservation.

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Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data

Oktay¹,

Marin²,

Bedoschi³

et al. 2022

Fertility and Sterility

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Successful autotransplantation of cryopreserved ovarian tissue with recovery of the ovarian function

Abstract: Cryopreservation and transplantation of ovarian tissue allowed to restore the ovarian function. It could offer an alternative physiological solution to treating premature ovarian failure caused by oncological therapy.

Cited by 7 publications

References 0 publications

Ovarian tissue cryopreservation by vitrification: The first Vietnam experience

Ovarian tissue cryopreservation by vitrification: The first Vietnam experience

Transplantation of frozen-thawed ovarian tissue: an update on worldwide activity published in peer-reviewed papers and on the Danish cohort

Ovarian transplantation with robotic surgery and a neovascularizing human extracellular matrix scaffold: a case series in comparison to meta-analytic data

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