Successful Chemotherapy for Congenital Malignant Gliomas: A Report of Two Cases

Tamiya, Takashi; Takao, Soichiro; Ichikawa, Tomotsugu; Chayama, Kazuaki; Date, Isao

doi:10.1159/000092362

Cited by 7 publications

(3 citation statements)

References 45 publications

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“…Very few patients survive more than a year, and those that do usually suffer a deteriorated quality of life, particularly in brain stem glioblastomas in children and young adults [6,7]. So far, only a few isolated cases of long-term survivors have been reported following the orthodox and traditional therapeutic approaches of maximal surgical resection, chemotherapy, immunotherapy and radiotherapy [8].…”

Section: Introductionmentioning

confidence: 99%

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Harguindey¹,

Orozco²,

Alfarouk

et al. 2019

IJMS

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The treatment of cancer has been slowly but steadily progressing during the last fifty years. Some tumors with a high mortality in the past are curable nowadays. However, there is one striking exception: glioblastoma multiforme. No real breakthrough has been hitherto achieved with this tumor with ominous prognosis and very short survival. Glioblastomas, being highly glycolytic malignancies are strongly pH-dependent and driven by the sodium hydrogen exchanger 1 (NHE1) and other proton (H+) transporters. Therefore, this is one of those pathologies where the lessons recently learnt from the new pH-centered anticancer paradigm may soon bring a promising change to treatment. This contribution will discuss how the pH-centric molecular, biochemical and metabolic perspective may introduce some urgently needed and integral novel treatments. Such a prospective therapeutic approach for malignant brain tumors is developed here, either to be used alone or in combination with more standard therapies.

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Section: Introductionmentioning

confidence: 99%

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Harguindey¹,

Orozco²,

Alfarouk

et al. 2019

IJMS

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“…Patients with GBM have an average survival time of 12 to 18 months from initial diagnosis and 6 to 9 months after recurrence [1,2]. …”

Section: Introductionmentioning

confidence: 99%

Resveratrol represses YKL-40 expression in human glioma U87 cells

et al. 2010

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BackgroundGlioblastoma multiforme (GBM) is the most malignant intracranial tumour that develops in both adults and children. Microarray gene analyses have confirmed that the human YKL-40 gene is one of the most over-expressed genes in these tumours but not in normal brain tissue. Clinical studies have shown that serum YKL-40 levels are positively correlated with tumour burden in addition to being an independent prognostic factor of a short relapse-free interval as well as short overall survival in patients with various cancers. Our previous study revealed that YKL-40 was closely correlated with the pathological grades of human primary astrocytomas and played a crucial role in glioma cell proliferation. Hence, YKL-40 could be an attractive target in the design of anti-cancer therapies.MethodsCell viability and invasion assays were performed to detect the cell proliferation and invasive ability of U87 cells induced by resveratrol (3, 5, 4'-trihydroxystilbene; Res) or YKL-40 small-interfering RNAs (siRNAs). In addition, the luciferase assay, real-time RT-PCR, western blotting, and ELISA were used to measure YKL-40 promoter activity, mRNA, and protein expression, respectively. The expressions of phosphor-ERK1/2 and ERK1/2 were determined by western blotting.ResultsRes inhibited U87 cell proliferation and invasion in vitro and repressed YKL-40 in U87 cells by decreasing the activity of its promoter and reducing mRNA transcription and protein expression in vitro. YKL-40 siRNA treatment also impaired the invasiveness of U87 cells. When U87 cells were cultured with 20 μM PD98059 (an ERK1/2 inhibitor) alone, with 20 μM PD98059 and 100 μM Res, or with 100 μM Res alone for 48 h, YKL-40 protein expression decreased most significantly in the Res-treated group. PD98059 partially reversed the decrease of YKL-40 protein expression induced by Res. Furthermore, phosphor-ERK1/2 expression was reduced by Res treatment in a time-dependent manner.ConclusionsWe demonstrated for the first time that Res represses YKL-40 expression in vitro; in addition, the ERK1/2 pathway is involved in this repression. This finding could extend the prospective use of Res in glioma research and enlarge the armamentarium for treating gliomas.

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“…6) The most common histological type is teratoma, present in one-third to onehalf of all cases, followed by medulloblastoma, astrocytoma, choroid plexus papilloma, and ependymoma. 3,4,8,9,[11][12][13][14][16][17][18][19][20] Congenital brain tumors show significant differences in etiology, histological type, topographic distribution, clinical presentation, and prognosis from tumors originating after the first year of life. 19) Massive congenital intracranial teratoma is a rare neoplasm with poor prognosis because the tumor tissue has already replaced most of the brain tissue before first identification on fetal ultrasonography.…”

Section: Introductionmentioning

confidence: 99%

Rapid Growth of Congenital Diffuse Brain Tumor Considered to Be Teratoma -Case Report-

Tsutsumi

Kondo

Yasumoto

et al. 2008

Neurol. Med. Chir.(Tokyo)

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Prenatal ultrasonography of a 17-year-old pregnant female detected ventriculomegaly of the fetus at 31 weeks of gestation. Her medical and family histories were unremarkable. Fetal magnetic resonance imaging taken at 33 weeks of gestation showed a tumorous lesion with ventriculomegaly. A male baby was delivered by cesarean section at 36 weeks of gestation. The Apgar scores were 9 and 9 at 1 and 5 minutes after the delivery, respectively. The head circumference at birth was 41.5 cm with bulging anterior fontanel, but no other congenital anomaly. He showed relatively good activity with satisfactory feeding. Computed tomography performed on postnatal day 5 revealed a massive brain tumor of mixed density, with multiple lobulation and cystic and calcified components. The tumor had rapidly grown with diffuse appearance. The patient underwent endoscopic biopsy with installation of an Ommaya reservoir to control the hydrocephalus on postnatal day 6. The tumor appeared hypervascular and bled profusely on resection maneuver, so the endoscopic procedure for histological verification was abandoned. Cerebrospinal fluid taken intraoperatively revealed marked elevation of the alpha-fetoprotein level and mild increase of the human chorionic gonadotropin level, strongly suggestive of teratoma. Neuroimaging performed on postnatal day 11 indicated significant additional tumor growth which occupied nearly the whole cranial cavity. His activity began to deteriorate on postnatal day 13 and he died of respiratory distress on the 15th day of life.

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Successful Chemotherapy for Congenital Malignant Gliomas: A Report of Two Cases

Cited by 7 publications

References 45 publications

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies

Resveratrol represses YKL-40 expression in human glioma U87 cells

Rapid Growth of Congenital Diffuse Brain Tumor Considered to Be Teratoma -Case Report-

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