Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study

Elgamal, Safa; McKinnon, Margaret C.; Ramakrishnan, Karuna; Joffe, Russell T.; MacQueen, Glenda

doi:10.1017/s0033291707001110

Cited by 130 publications

(84 citation statements)

References 34 publications

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“…They also reported a decrease of ADHD related symptoms, anxiety, and depression. However, "classical neuropsychological therapy" has also been proved to be successful in affective disorders disorders (Elgamal et al 2007;Naismith et al 2010;Trebo et al 2007) but these treatment strategies could very likely be further optimised by considering the here discussed factors.…”

Section: Discussionmentioning

confidence: 99%

“…Given the high clinical relevance of neuropsychological deficits, effective neuropsychological treatment strategies are needed. The first interventional studies used treatment strategies that were originally developed for brain damaged patients (Elgamal et al 2007;Naismith et al 2010;Trebo et al 2007). The results raised hope that cognitive deficits in affective disorders are successfully treatable.…”

Section: Introductionmentioning

confidence: 99%

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Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

2011

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Neuropsychological research in patients with affective disorders shows heterogeneous results with regard to the severity and profile of cognitive impairments. In this paper we hypothesize that the investigation of clinical (subtypes, comorbidity, traumatization, personality, severity, diurnal swings, course, duration, age of onset, biased processing, rumination, motivation, experience of failure, sleep, suicidal tendencies, computer attitudes), demographic (age, education, gender) and neurobiological factors (structural and functional brain changes, glucocorticoids, medication, ECT) that are related to cognitive performance has specified the understanding of severity and profile of neuropsychological impairments. We reviewed the literature pertaining to clinical, demographic and neurobiological factors following Pubmed and PsychInfo databases using different combinations of general key-terms including "Affective Disorder," "Depression," "Mania," "Neuropsychological," "Neurobiological," "Moderator," and "Review" as well as more specific demographic, clinical and neurobiological search terms. Findings from the literature show that the consideration of these factors has improved knowledge about the severity of neuropsychological impairments in patients with affective disorders whereas the neuropsychological profile is still poorly understood. Despite limited understanding, however, the existent results provide promising suggestions for the development of treatment programs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

2011

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“…Only two clinical trials of this meta-analysis examined the impact of CCT on stable patients with MDD without psychotic symptoms [59,62]: Elgamal et al [59], for example, demonstrated improvement under CRT in several neuropsychological tests regarding attention, verbal learning and memory, psychomotor speed, and executive function in n = 12 outpatients with long-term illness with stable depressive symptom scores over a time period of ten weeks. Naismith et al [62] investigated n = 41 stabilized outpatients on medication with a lifetime history of major depression and depressive symptoms in the normal to mild range.…”

Section: Cognitive Remediation Therapymentioning

confidence: 99%

Cognitive Impairment Along the Course of Depression: Non-Pharmacological Treatment Options

et al. 2018

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Major Depressive Disorder (MDD) is one of the most common psychiatric disorders, with a large global impact on both the individual and the society. In this narrative review, we summarize neurocognitive deficits during acute and (partially) remitted states of depression. Furthermore, we outline the potential negative effect of cognitive impairment (CI) on functional recovery, and discuss the role of several variables in the development of CI for MDD patients. Though there is cumulating evidence regarding persistent CI in unipolar depression, research on treatment options specific for this patient group is still scarce. Hence the central aim of our review is to present non-pharmacological interventions, which are thought to reduce CI in affected MDD patients. We discuss cognitive remediation therapy (CRT), physical exercise, yoga, mindfulness-based therapy, and modern neuromodulation approaches like neurostimulation and neurofeedback training. In conclusion, we propose future directions for research on CI in depression. Looking further ahead, we suggest creative interventional designs that include a direct comparison of different non-pharmacological treatment approaches on neurocognition and functional outcome of MDD. Furthermore, additive and synergistic effects of CRT with other treatment approaches should be examined and compared to create multimodal and even personalized intervention programs.

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“…The modified intervention, functional remediation, 512 has not yet been evaluated, but rigorous investigation is warranted given growing evidence that supports the use of CR for individuals with affective disorders. 506,513,514 Older Individuals With Serious Mental Illnesses Not unlike many other subgroups described within this report, the mental health and substance-use needs of older adults are complex and frequently unmet by today's health care delivery system. Bartels 515 described the "forgotten territory" in policy advocacy that older adults with serious mental illnesses occupy.…”

Section: Individuals In Need Of Daily Living Assistance or Social Skimentioning

confidence: 87%

Directions for Future Patient-Centered and Comparative Effectiveness Research for People With Serious Mental Illness

Green¹,

Estroff²,

Yarborough³

et al. 2014

Schizophrenia Bulletin

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Successful computer-assisted cognitive remediation therapy in patients with unipolar depression: a proof of principle study

Abstract: These results provide preliminary evidence that improvement of cognitive functions through targeted, repetitive exercises is a viable method of cognitive remediation in patients with recurrent MDD.

Cited by 130 publications

References 34 publications

Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

Specifying the Neuropsychology of Affective Disorders: Clinical, Demographic and Neurobiological Factors

Cognitive Impairment Along the Course of Depression: Non-Pharmacological Treatment Options

Directions for Future Patient-Centered and Comparative Effectiveness Research for People With Serious Mental Illness

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