Successful correction of ichthyosis‐related ectropion by autografts

Abstract

Ectropion is a rather frequent complication of ichthyosis with negative functional and esthetic impact. Lid surgery can provide significant improvement. We report on a series of four ichthyosis patients with ongoing bilateral eye problems despite intense medical treatment (mean age 27.8 ± 14.1 years). All patients suffered from 2 | MATERIALS AND METHODS This study protocol was approved by the local Institutional Review Board and was conducted in accordance with the Declaration of

Management of Harlequin Ichthyosis: A Brief Review of the Recent Literature

“…Infants are at a higher risk for developing strabismus, conjunctivitis, and keratitis. Even though the recommendations for eyelid treatment include the application of ophthalmic ointment upon the eyelids margin, surgical interventions have also been reported [ 36 , 37 ]. More specifically, surgical interventions focused on the full-thickness autografts from engineered human skin and from the posterior auricular skin.…”

“…More specifically, surgical interventions focused on the full-thickness autografts from engineered human skin and from the posterior auricular skin. There is no evidence that early surgery decreased the possibility for ectropion in a timeframe of 6 to 12 months [ 36 , 37 ].…”

“…More specifically, surgical wounding increases the possibility of infection, one of the primary risk factors for neonatal morbidity [ 31 ]. The literature recommends the use of antibiotics, topically applied, until the surgical wounds are fully healed [ 37 , 38 , 39 ]. Indeed, a recent case reported that implementation of topical antibiotics prevented completely the infection of the surgical wound [ 39 ].…”

Ectropion surgery might not be a long‐term solution for harlequin ichthyosis

“…Our case was a 30-year-old gentleman with ectropion recurrence as early as a few follow-up. 5 However, none of them had harlequin ichthyosis. In such cases, the problem is more challenging as there is no appropriate skin for grafting which adds to the routine subdermal scarring produced.…”

“…On the other hand, Karadag presented four individuals with ichthyosis-related ectropion repair who revealed neither lagophthalmos nor corneal exposure after 23 ± 12.7 months of follow-up. 5 However, none of them had harlequin ichthyosis. In such cases, the problem is more challenging as there is no appropriate skin for grafting which adds to the routine subdermal scarring produced.…”