Successful Eltrombopag treatment of refractory idiopathic thrombocytopenic purpura associated with Crohn disease

Rassy, Elie El; Kourié, Hampig Raphaël; Nehme, William; Georges, Samuel; Haddad, Élie; Nasnas, R; Nasr, Fadi

doi:10.1016/j.clinre.2014.10.011

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…With regard to colectomy, whose efficacy on platelet count is often but not always found [ 1 , 12 , 22 , 26 , 27 , 32 , 40 , 41 , 42 ], it resulted in complete recovery from ITP in both of the 2 surgically treated patients of our series, but one of them exhibited an early ITP relapse only 4 weeks after colectomy: on this basis, in our opinion, it seems impossible to predict whether colectomy may have a definitive curative role in both ITP and IBD. Finally, we report 3 IBD/ITP children who, to the best of our knowledge, were the first to be treated with eltrombopag, a few of whom grew to adulthood [ 43 ]: all of them presented a sustained platelet response.…”

Section: Discussionmentioning

confidence: 99%

Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children

Guarina

Barone²,

Tornesello

et al. 2021

JCM

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Background: The association between inflammatory bowel disease (IBD) and immune thrombocytopenia (ITP) is still uncertain. In this multicenter retrospective study, the coexistence of both diseases was investigated in children diagnosed from 1 January 2000 to 31 December 2019. Methods: Clinical characteristics of both IBD and ITP, onset of disorders, and patient’s response to treatment were collected through a structured form sent to 55 Italian pediatric referring centers for hematological disorders. Result: Centers responded to the survey and reported the coexistence of IBD and ITP in 14 children. The first diagnosis was ITP in 57.1% and IBD in 35.7% of patients: it was simultaneous in 7.1%. IBD was classified as ulcerative colitis (57.1%), Crohn disease (35.7%), and unclassified (7.1%). No therapy for IBD other than steroids had any effect on ITP course. Colectomy resulted in recovery from ITP in 1 of the 2 patients surgically treated. ITP was always mild but turned to be chronic in half of patients. Conclusions: In all patients, ITP was mild without any evident impact on IBD severity, but the incidence of chronic ITP seems to be higher than what is usually observed in the pediatric age group. Colectomy had unpredictable effects on ITP.

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Section: Discussionmentioning

confidence: 99%

Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children

Guarina

Barone²,

Tornesello

et al. 2021

JCM

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“…Such reaction confirms the immune-related etiology of TIT. Our patient had refractory Crohn's disease which hypothetically increases the exposure of the humor immune system to colonic antigens which increases the formation of anti-GP IIb/IIIa antibodies [ 9 ]. The exposure of our patient to tirofiban, in the presence of anti-GP IIb/IIIa inhibitors, induced an allergic reaction that heralded the occurrence of thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

Tirofiban-Induced Thrombocytopenia Occurring with Crohn’s Disease

Ibrahim¹,

Karak

Araji³

et al. 2016

Case Reports in Cardiology

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A 69-year-old man, with severe refractory Crohn's disease, presented with acute coronary syndrome that required angioplasty. He developed severe tirofiban-induced thrombocytopenia (TIT) heralded by type I allergic reaction that required steroids and a combination of antihistamine H1 and antihistamine H2 for symptomatic management. The thrombocytopenia spontaneously resolved uneventfully in 48 hours thereafter. This case report suggests a possible association between TIT and inflammatory bowel disease. Therefore, strict monitoring of the platelet count is required in patients who develop allergic reactions to tirofiban.

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Diagnosis and Treatment of Inflammatory Bowel Disease–Associated Bleeding

Shen

2018

Interventional Inflammatory Bowel Disease: Endoscopic Management and Treatment of Complications

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Successful Eltrombopag treatment of refractory idiopathic thrombocytopenic purpura associated with Crohn disease

Cited by 5 publications

References 6 publications

Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children

Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children

Tirofiban-Induced Thrombocytopenia Occurring with Crohn’s Disease

Diagnosis and Treatment of Inflammatory Bowel Disease–Associated Bleeding

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