Successful embryo cryopreservation immediately following a full-term delivery in a woman with newly diagnosed Ewing’s sarcoma

Giuliani, Emma; Ellman, Erin; Chugh, Rashmi; Moravek, Molly B.

doi:10.1007/s10815-019-01445-6

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…One example is the management of FP immediately after pregnancy, which was discussed in our group during time of analysis. While the rst description of a similar case was rst published in 2019 [9], actual experience in this situation was shared in the discussion group by clinicians from three centers. This demonstrates how online communication can e ciently summarize clinical approaches and experience of many clinicians when information in standard medical literature is limited.…”

Section: Discussionmentioning

confidence: 99%

What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group

Tsafrir

Ben-Haroush

Hyman

et al. 2023

Preprint

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Research Question Clinicians involved in fertility preservation (FP) are often required to make prompt and consequential decisions despite the absence of evidence-based data. We established a collaborative professional online consultation group for fertility preservation issues. We sought to determine the main controversial clinical issues in FP as raised by participants of this group. Design Content analysis of a dedicated community of practice interacting via a messaging application (WhatsApp) and a survey of group participants. Results Between January 2019 and July 2022, group members posed 39 clinical questions which were discussed and debated by the group. Common themes included management of oncofertility cases (33%), potential gonadotoxicity of various therapies (23 %), fertility preservation in women and girls with premature ovarian insufficiency (POI) (18%), and technical aspects of ovarian tissue cryopreservation (10%). All but one query received prompt response (mean time for first response for 95% of queries 7.1±9.0 minutes) from a mean of 5.4±3.2 members. An anonymous online survey of group members was conducted during August 2022 (n=31, response rate 94%). The majority of respondents stated they gained knowledge and assistance in clinical decision making from participation in the discussion group (90% and 58% of respondents, respectively). Conclusions Management of clinical oncofertility cases, potential gonadotoxic effect of therapeutics and fertility preservation in women and girls with POI were the most common controversial issues in our fertility preservation community of practice. Intra-professional collaborative communication via a messaging application can aid in clinical management of fertility preservation and augment clinician’s knowledge.

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Section: Discussionmentioning

confidence: 99%

What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group

Tsafrir

Ben-Haroush

Hyman

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…One example is the management of FP immediately after pregnancy, which was discussed in our group during time of analysis. While the first description of a similar case was first published in 2019 [ 9 ], actual experience in this situation was shared in the discussion group by clinicians from three centers. This demonstrates how online communication can efficiently summarize clinical approaches and experience of many clinicians when information in standard medical literature is limited.…”

Section: Discussionmentioning

confidence: 99%

What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group

Tsafrir,

BenHaroush,

Hyman

et al. 2023

Reprod Biol Endocrinol

View full text Add to dashboard Cite

Research question Clinicians involved in fertility preservation (FP) are often required to make prompt and consequential decisions despite the absence of evidence-based data. We established a collaborative professional online consultation group for fertility preservation issues. We sought to determine the main controversial clinical issues in FP as raised by participants of this group. Design Content analysis of a dedicated community of practice interacting via a messaging application (WhatsApp) and a survey of group participants. Results Between January 2019 and July 2022, group members posed 39 clinical questions which were discussed and debated by the group. Common themes included management of oncofertility cases (33%), potential gonadotoxicity of various therapies (23%), fertility preservation in women and girls with premature ovarian insufficiency (POI) (18%), and technical aspects of ovarian tissue cryopreservation (10%). All but one query received prompt response (mean time for first response for 95% of queries 7.1 ± 9.0 min) from a mean of 5.4 ± 3.2 members. An anonymous online survey of group members was conducted during August 2022 (n = 31, response rate 94%). The majority of respondents stated they gained knowledge and assistance in clinical decision making from participation in the discussion group (90% and 58% of respondents, respectively). Conclusions Management of clinical oncofertility cases, potential gonadotoxic effect of therapeutics and fertility preservation in women and girls with POI were the most common controversial issues in our fertility preservation community of practice. Intra-professional collaborative communication via a messaging application can aid in clinical management of fertility preservation and augment clinician’s knowledge.

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Rare Tumors in Pregnancy: A Case Report of Ewing’s Sarcoma and Systematic Review

La Verde,

Marrapodi,

Iavarone

et al. 2024

Indian J Gynecol Oncolog

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Purpose Ewing’s sarcoma during pregnancy is a rare tumor that poses significant challenges in terms of early diagnosis and proper management. The early symptoms are often nonspecific. Management requires a tailored approach that considers multiple factors. Methods PubMed, Scopus, Cochrane Library and EMBASE were screened from the first record appearing up to January 2023, through Mesh Items which were related both to pregnancy and Ewing’s sarcoma. Reviewers extracted data, in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) Statement. Results Fifteen papers with 15 pregnant women were included. Eleven patients were young nulliparous. The mean gestational age at diagnosis was 26 weeks. The primary sites of tumor involvement were bone, kidney and uterine cervix. One patient underwent external-beam radiation therapy (EBRT) during pregnancy. Four patients received prepartum chemotherapy (CT), resulting in healthy deliveries, except for one case of fetal death. Cesarean sections were the primary delivery method in 50% of cases, but vaginal delivery was possible in three patients (25%). Maternal mortality analysis revealed that 4 over 13 patients (30.8%) died during postpartum follow-up (FU). One patient experienced recurrence (7.7%), and eight showed no evidence of disease (61.5%). Fetal survival was 72.7%. One study reported intrauterine fetal death (9.1% of fetal mortality), whereas two patients performed induced abortion (18.2%). Conclusion The limited available data indicate that the prognosis for Ewing’s sarcoma during pregnancy is poor, with high maternal mortality. Further research is needed to understand the complex interactions between pregnancy and Ewing’s sarcoma.

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Successful embryo cryopreservation immediately following a full-term delivery in a woman with newly diagnosed Ewing’s sarcoma

Cited by 3 publications

References 9 publications

What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group

What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group

What are the most common controversial clinical issues in fertility preservation? A content analysis of a collaborative professional online consultation group

Rare Tumors in Pregnancy: A Case Report of Ewing’s Sarcoma and Systematic Review

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