Rural economically disadvantaged communities face unique challenges in engaging students in science, technology, engineering, and mathematics (STEM). School district administrators, teachers, and students do not have access to high-quality STEM opportunities compared to urban schools. This article describes a partnership between a small, private STEM university and a network of school districts scattered across the geographically isolated region of upstate New York. The partnership’s primary goal is to support the teaching and learning of STEM. This is achieved through actively engaging a range of university and community stakeholders in STEM enrichment and professional development. Programming includes summer camps and after-school activities, challenges and competitions that focus on inspiring students to pursue STEM careers, undergraduate and graduate student mentors, and a university curriculum designed to prepare teachers to work in high-need school districts. Activities are supported by the university’s Institute for STEM Education, which fosters collaborations for like-minded faculty and campus members to pursue grant opportunities and connect with community members. The paper describes various program components and how they work to support each other, discusses impacts of the program, and describes ways in which elements can be implemented elsewhere.