Successful Intra-arterial Thrombolysis in a Patient with an Intracranial Meningioma

Baiense, Robson Fantinato; Abrahão, Agessandro; Ricarte, Irapuá Ferreira; Fukuda, Thiago Yukio; Oliveira, Ricardo Araújo de; Silva, Gisele Sampaio; Costa, Maristela; Teixeira, Manoel J.

doi:10.1016/j.jstrokecerebrovasdis.2013.05.009

Cited by 5 publications

(5 citation statements)

References 10 publications

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“…We did not observe any bleeding complications associated with the use of t-PA in patients with benign intracranial tumor or cavernoma. Our data are therefore in line with previously published observations of either intra-arterial or systemic thrombolysis for ischemic stroke 3 – 6 , 12 – 14 or myocardial infarction 7 , 8 in patients with benign intracranial tumor, and also contribute to the positive safety results reported in patients with cavernoma. 15 , 17 However, we did observe independent intracranial hemorrhage following thrombolysis in one of the two patients with malignant intracranial neoplasm.…”

Section: Discussionsupporting

confidence: 92%

“… 3 – 13 Based upon these reports, systemic thrombolysis has been repeatedly discussed as a feasible option for selected patients with benign intracranial tumor. 3 , 6 , 8 , 13 The same conclusion was drawn from the single population-based analysis on the matter. 14 Treatment of these patients, however, is beyond the approval of the Food and Drug Administration.…”

Section: Introductionmentioning

confidence: 99%

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Off-label use of IV t-PA in patients with intracranial neoplasm and cavernoma

Schwarzbach

Ebert

Hennerici

et al. 2018

Ther Adv Neurol Disord

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Background:The safety of systemic thrombolysis in patients with intracranial tumor and cavernoma are unknown. So far evidence is limited to a number of case reports and few case series or unspecified data based on population-based analysis. Our aim was to comprehend the risk of systemic thrombolysis in these patients.Methods:Patients with additional evidence of intracranial tumor or cavernoma who received IV tissue plasminogen activator (t-PA) treatment at our comprehensive stroke center over a period of 7 years were identified in our stroke database and compared to the same number of matched control subjects without any evidence of intracranial tumor and cavernoma. Clinical history and imaging patterns before and after t-PA therapy were individually reviewed for each patient.Results:Thirty-four patients with additional evidence of meningioma (19/34), cavernoma (13/34) or malignant intracranial neoplasm (2/34) were identified. The incidence of secondary intracranial hemorrhage observed showed no difference between control subjects (9/34, 26%) and patients (6/34, 18%; p = 0.56). Symptomatic hemorrhage in patients with meningioma or cavernoma could not be observed. Likewise, the prevalence of stroke mimics showed no difference between patients (8/34, 24%) and control subjects (5/34, 15%; p = 0.54). However, both patients with malignant intracranial neoplasm presented with a stroke mimic and intracranial hemorrhage was observed in one of them.Conclusions:In compliance with existing evidence, treatment in patients with meningioma and cavernoma appears to be safe and reasonable, while the therapy should be avoided in patients with malignant intracranial neoplasm with blood–brain barrier disruption.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Off-label use of IV t-PA in patients with intracranial neoplasm and cavernoma

Schwarzbach

Ebert

Hennerici

et al. 2018

Ther Adv Neurol Disord

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“…In a review of 12 patients with BTS treated with intravenous thrombolysis, ICH occurred in only one patient who had a glioblastoma, while there were no complications in the other patients with benign brain tumors [9]. There are also anecdotal reports of successful intra-arterial thrombolysis for AIS in the setting of benign brain tumors [18]. We did not have access to the histopathology of the brain tumors.…”

Section: Discussionmentioning

confidence: 99%

In-hospital outcomes of thrombolysis for acute ischemic stroke in patients with primary brain tumors

Murthy

Moradiya

Shah

et al. 2015

Journal of Clinical Neuroscience

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“…The management of our patient was not optimal, due to the limitations of radiological explo-rations and neurosurgery conditions in Congo. Without others contraindications thrombolysis with rt-PA can be used in acute stroke associated to meningioma [11,12] and, in some cases endovascular treatment was used before tumor surgery [10]. In our case, partial recovery of neurological impairment is due to steroid treatment and early rehabilitation, because outcome depend on treatment and early rehabilitation [13].…”

Section: Discussionmentioning

confidence: 84%

Anterior Cerebral Infarction by Fronto-Basal Meningioma

Ossou-Nguıet¹,

Gnonlonfoun²,

Obondzo-Aloba³

et al. 2013

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The association between stroke and meningioma is rarely reported in the data. In most etiology classification, there is no compressive cause. The association between meningioma and stroke is increasingly reported. We report a case of 52year-old woman, previously healthy, presented with sudden right hemiplegia with some transient mood disorders. The CT-scan revealed acute left anterior cerebral artery infarction associated with fronto-basale meningioma infiltrating both anterior cerebral arteries. She was treated by corticosteroid and rehabilitation, with partial recovery. No stroke prevention was used before surgical treatment.

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Successful Intra-arterial Thrombolysis in a Patient with an Intracranial Meningioma

Cited by 5 publications

References 10 publications

Off-label use of IV t-PA in patients with intracranial neoplasm and cavernoma

Off-label use of IV t-PA in patients with intracranial neoplasm and cavernoma

In-hospital outcomes of thrombolysis for acute ischemic stroke in patients with primary brain tumors

Anterior Cerebral Infarction by Fronto-Basal Meningioma

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