Successful Kidney Transplantation From a Hepatitis B Surface Antigen–Positive Donor to an Antigen-Negative Recipient Using a Novel Vaccination Regimen

The Outcomes of Kidney Transplantation in Hepatitis B Surface Antigen (HBsAg)–Negative Recipients Receiving Graft From HBsAg-Positive Donors: A Retrospective, Propensity Score-Matched Study

“…In several parts of the world where HBsAg carrier rates can be greater than 10%, exclusion of HBsAg(þ) donors significantly limits the supply of kidney allografts (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). In KT, the major concern of KT from HBsAg(þ) donors to …”

“…Thus, the recipients obtained lamivudine for HBV prophylaxis during the early period (2000-2007) of the study. Later studies showed excellent results with no lamivudine use (1)(2)(3)(4)6,8,10,11). As such, the recipients in the later period of the study did not receive lamivudine.…”

“…To cope with the shortage of organ transplantation worldwide, several strategies, including the transplantation of hepatitis B surface antigen (HBsAg)-positive [HBsAg(þ)] allografts to HBsAg-negative [HBsAg(À)] recipients, have been adopted for expanding the number of deceased donor pool (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Since hepatitis B virus (HBV)-infection is a blood-borne transmission, HBV carried by the transplanted organs can infect the HBsAg(À) recipients and might cause hepatic diseases, ranging from acute self-limited as well as fulminant hepatitis to chronic hepatitis, cirrhosis, and hepatocellular carcinoma, and HBV-related organ disorders.…”

Living-Donor Kidney Transplant From Hepatitis B Surface Antigen-Positive Donors to Hepatitis B Antibody-Positive Recipients Without Hepatitis B Immunoglobulin Prophylaxis in an Endemic Country

“…6 Living-donor kidney transplant from HBsAgpositive donors to hepatitis B antibody-positive recipients were reported in only 45 cases in Hong Kong, Saudi Arabia, Turkey, and the United States. [1][2][3]5,6 These data came from endemic areas, where the prevalence of natural immunity was high.…”

“…Due to the shortage of renal grafts and the good outcome of hepatitis B virus (HBV) infection with medication, kidney transplant with HBV-infected deceased donors has been accepted generally. [1][2][3][4] However, kidney transplant from HBV-infected living donors has been avoided due to the possibility of graft instability and HBV transmission, except in some studies. 5 In this study, living-donor kidney transplant from chronically HBV-infected donors was considered as a possibility to compensate for insufficiency of organ transplants, particularly in an HBV-endemic country where many potential donors are already infected.…”