Successful Labeling of^99mTc-MDP Using^99mTc Separated from⁹⁹Mo Produced by¹⁰⁰Mo(n,2n)⁹⁹Mo

Abstract

Mo by sublimation and its radionuclide purity was confirmed to be higher than 99.99% by -spectroscopy. The labeling efficiency of 99m Tc-MDP was shown to be higher than 99% by thin-layer chromatography. These values exceed the United States Pharmacopeia requirements for a fission product, 99 Mo. Consequently, a 99m Tc radiopharmaceutical preparation formed by using the mentioned 99 Mo can be a promising substitute for the fission product 99 Mo, which is currently produced using a highly enriched uranium target in aging research reactors. A longstanding problem to ensure a reliable and constant supply of 99 Mo in Japan can be partially mitigated.

Research opportunities with compact accelerator-driven neutron sources

“…Dovbnya et al [178] investigated the 98 Mo(n,) 99 Mo 99m Tc reaction and speculated on the feasibility of producing the 99m Tc radioisotope using a neutron generator of a thermal-neutron flux ~10 2 n/cm 2 /s. Nagai et al [179,180] exploited the substantial cross section of the 100 Mo(n, 2n) 99 Mo reaction in the neutron energy range of 12-17 MeV (~1.5 b) and demonstrated the production of 79-GBq/g specific activity of 99 Mo after irradiating an enriched 100 Mo target for 198 h with a 14-MeV neutron flux of ~10 13 n/cm 2 /s. The demand for 99 …”

99Mo Production via100Mo(n,2n)99Mo using accelerator neutrons

“…Labeling efficiency was higher than 95% by formulating a radiopharmaceutical by using commercially available methylene diphosphonate (MDP) (FUJIFILM RI Pharma) kits, which is used for bone scans more than 50% of all routine 99m Tc scans currently used in diagnostic nuclear medicine. The radionuclide purity of 99m Tc and labeling efficiency were above the USP requirement [12]. Note that a thermochromatographic separation allows us to recycle any irradiated enriched 100 Mo.…”

Generation of Radioisotopes with Accelerator Neutrons by Deuterons

“…Among the methods, the sublimation method is based on a different volatility of technetium heptoxide (Tc 2 O 7 ) and molybdenum trioxide (MoO 3 ); 99m Tc produced in MoO 3 volatilizes at a temperature lower than that of the sublimation of MoO 3 , which is 790 C. In fact, we successfully used the sublimation method, as briefly discussed below. 10) 99 Mo was produced by irradiating a 100 MoO 3 sample with $14 MeV neutrons at JAEA. The sublimation separation of 99m Tc from the 100 MoO 3 sample was performed by using a furnace, which consisted of a three-stage quartz tube, as shown in Fig.…”

“…9) Since then, we have carried out all important steps necessary to obtain 99m Tc with high-quality using 99 Mo, which was produced using fast neutrons from an existing accelerator; these results are published elsewhere. 10) On the basis of the results, we present here a prototype facility for the Generation of Radioisotopes with Accelerator Neutrons by Deuterons (GRAND). The paper is comprised of four-sections.…”