Successful Long-Term Treatment with Linezolid for Disseminated Infection with Multiresistant Nocardia farcinica

“…Antimicrobial sensitivity testing has shown that it has excellent activity against all species of Nocardia, including N. farcinica (59) (92)(93)(94)(95)(96)(97). Linezolid is given 600 mg twice a day and can be given either intravenously or orally.…”

Section: Linezolid Is An Oxazolidinone Antibiotic Which Is Gaining Momentioning

confidence: 99%

Nocardia in Solid Organ Transplant Recipients

Clark

2009

American Journal of Transplantation

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“…Fifteen cases of nocardiosis treated with linezolid have been published to date (Table 1) [6][7][8][9][10][11][12][13][14][15]. Linezolid has a well-documented short-term adverse effect profile, with headache and diarrhea most commonly seen; however, its long-term safety profile ([28 days) has not been extensively studied.…”

Section: Discussionmentioning

confidence: 99%

Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review

Tanioka

Nagao

Yamamoto

et al. 2012

Journal of Infection and Chemotherapy

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Nocardiosis is increasingly being diagnosed because of a growing population of immunocompromised hosts and improvements in the detection of Nocardia species in clinical laboratories. Historically, sulphonamides have been the first-line therapy for the treatment of nocardiosis, but sulphonamides tend to have a high rate of drug allergy in clinical settings. In this report, we described a disseminated Nocardia farcinica infection that occurred in a patient with myasthenia gravis who suffered from multiple drug allergies and was successfully treated using linezolid. We undertook a review of the literature of previously reported cases of nocardiosis treated with linezolid. To date, only 15 cases of nocardiosis treated with linezolid have been published. All cases exhibited long-term tolerance of linezolid, and 14 of 15 cases showed either an improvement in or complete clearance of the infection. According to the literature review, linezolid is an attractive alternative to trimethoprim-sulfamethoxazole for the treatment of disseminated nocardiosis, despite limited clinical evidence to support this claim.

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Successful Long-Term Treatment with Linezolid for Disseminated Infection with Multiresistant Nocardia farcinica

Cited by 23 publications

References 21 publications

First Case of Cerebral Abscess Due to a Novel Nocardia Species in an Immunocompromised Patient

First Case of Cerebral Abscess Due to a Novel Nocardia Species in an Immunocompromised Patient

Nocardia in Solid Organ Transplant Recipients

Disseminated Nocardia farcinica infection in a patient with myasthenia gravis successfully treated by linezolid: a case report and literature review

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