Successful Management of a Patient with Multiple Nucleos(t)ide Analogue-Resistant Hepatitis B Virus and Diffuse Large B Cell Lymphoma Using Tenofovir Disoproxil Fumarate: A Case Report

Abstract

Background: Malignant lymphoma is occasionally observed in chronic hepatitis B virus (HBV)-infected patients. The occurrence of HBV reactivation or acute exacerbation of chronic hepatitis B during and after chemotherapy and immunosuppressive therapies is a major issue.Case presentation: We reported a 65-year-old Japanese man with multiple nucleos(t)ide analogue (NUC)resistant HBV infection and diffuse large B cell lymphoma (DLBCL), stage IV. The patient was treated with the addition of tenofovir disoproxil fumarate to entecavir and chemotherapy to control the HBV and treatment of lymphoma, respectively. Both diseases were safely controlled.Conclusion: Clinicians should pay careful attention to NUC-resistant HBV and select the proper NUCs to control the virus before and during the commencement of chemotherapy.