Successful management of deep facial burns in a patient with extensive third‐degree burns: the role of a nanocrystalline silver dressing in facilitating resurfacing

Marazzi, Mario; Angelis, Armando De; Ravizza, A.; Ordanini, Marco N.; Falcone, Laura; Chiaratti, A.; Crovato, F.; Calò, Donata; Veronese, Silvio; Rapisarda, Vincenzo

doi:10.1111/j.1742-481x.2006.00263.x

Cited by 8 publications

(5 citation statements)

References 21 publications

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“…Autologous grafting was performed at 23 ± 9 days after the last silver dressing application. Healing times recorded for burn wounds are consistent with the data previously reported by other authors [34,57,58]. Khundkar et al [20] demonstrated that Ag NP-based dressings are effective in reducing the time for re-epithelialization and the requirement for grafting in comparison to other treatment widely used in burn centers, such as silver sulfadiazine and 0.01% neomycin and polymyxin solution.…”

Section: Resultssupporting

confidence: 87%

Active Silver Nanoparticles for Wound Healing

Rigo

Ferroni

Tocco

et al. 2013

IJMS

268

162

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In this preliminary study, the silver nanoparticle (Ag NP)-based dressing, Acticoat™ Flex 3, has been applied to a 3D fibroblast cell culture in vitro and to a real partial thickness burn patient. The in vitro results show that Ag NPs greatly reduce mitochondrial activity, while cellular staining techniques show that nuclear integrity is maintained, with no signs of cell death. For the first time, transmission electron microscopy (TEM) and inductively coupled plasma mass spectrometry (ICP-MS) analyses were carried out on skin biopsies taken from a single patient during treatment. The results show that Ag NPs are released as aggregates and are localized in the cytoplasm of fibroblasts. No signs of cell death were observed, and the nanoparticles had different distributions within the cells of the upper and lower dermis. Depth profiles of the Ag concentrations were determined along the skin biopsies. In the healed sample, most of the silver remained in the surface layers, whereas in the unhealed sample, the silver penetrated more deeply. The Ag concentrations in the cell cultures were also determined. Clinical observations and experimental data collected here are consistent with previously published articles and support the safety of Ag NP-based dressing in wound treatment.

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Section: Resultssupporting

confidence: 87%

Active Silver Nanoparticles for Wound Healing

Rigo

Ferroni

Tocco

et al. 2013

IJMS

268

162

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“…Whereas the clinical efficacy of Acticoat7™ has been the focus of interest in adults with superficial partial thickness burns [12] as well as in pediatric populations with different burn depths [13][14][15] and also in several previous case reports [16,17], our aim was to evaluate its value in the conservative treatment of superficial and especially deep partial thickness wounds of the face.…”

Section: Discussionmentioning

confidence: 99%

Treatment of partial thickness burns of the face with Acticoat7™

Nedomansky

Oramary

Nickl

et al. 2020

Wien Klin Wochenschr

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Summary Background The face is affected in more than 50% of patients with extensive burn trauma. Effective treatment is of importance to avoid hypertrophic scarring, functional impairment and social stigmatization. Material and methods All patients treated with Acticoat7™ due to superficial and deep partial thickness burns of the face between 2008 and 2017 at the intensive care unit (ICU) for burn trauma at the Department for Plastic and Reconstructive Surgery of the Medical University of Vienna were retrospectively analyzed. Patients were evaluated for the number of required dressing changes until complete re-epithelialization, bacterial colonization, potential complications and the need for primary and secondary surgery. Results A total of 100 patients were analyzed. It took a median dressing change rate of 1 (range 0–5) in the superficial partial thickness and 3 (range 1–11) in the deep partial thickness group. Conservative treatment of deep partial thickness wounds was possible in 79% and 17% of these patients required secondary scar revision. Although bacterial colonization of the wounds frequently occurred, wound infections were rarely observed. Conclusion Acticoat7™ is a valuable dressing for treating superficial and deep partial thickness burn wounds of the face in an intensive care unit setting. It enables extended time intervals between dressing changes without an increased risk for complications.

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“…Patients were then treated with keratinocytes on Laserskin ® or with fibroblasts on Hyalograft 3D R ; the construct number for each patient was adapted to totally cover the wound, including the margins. Finally, the wounds were treated with a secondary dressing composed of nanocrystalline silver (Acticoat; Smith & Nephew Medical Ltd, UK; ).…”

Section: Methodsmentioning

confidence: 99%

Skin substitutes based on allogenic fibroblasts or keratinocytes for chronic wounds not responding to conventional therapy: a retrospective observational study

Pajardi

Rapisarda

Somalvico³

et al. 2014

International Wound Journal

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Chronic wounds are an expression of underlying complex pathologies and have a high incidence. Skin substitutes may represent an alternative approach to treat chronic ulcers. The aim of this retrospective observational study was to evaluate the wound reduction using skin substitutes based on allogenic fibroblasts or keratinocytes in 30 patients not responding to conventional therapy. Wound bed was prepared, then keratinocytes on Laserskin(®) to treat superficial wounds or fibroblasts on Hyalograft 3D(R) to treat deep leg ulcers were applied, and finally wounds were treated with a secondary dressing composed of nanocrystalline silver. Once a week constructs were removed and new bioengineered products were applied, as well as nanocrystalline silver medication. In none of the cases under examination did any complications arise relating to the treatment. We also achieved a reduction in wound dimension and exudates, and an increase in wound bed score. Postoperative assessment shows a degree of healing that is statistically higher in the group treated with keratinocytes as compared with the fibroblast group. This retrospective study improves our understanding and defines the clinical indications for the various uses of the two types of skin substitutes.

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Successful management of deep facial burns in a patient with extensive third‐degree burns: the role of a nanocrystalline silver dressing in facilitating resurfacing

Cited by 8 publications

References 21 publications

Active Silver Nanoparticles for Wound Healing

Active Silver Nanoparticles for Wound Healing

Treatment of partial thickness burns of the face with Acticoat7™

Skin substitutes based on allogenic fibroblasts or keratinocytes for chronic wounds not responding to conventional therapy: a retrospective observational study

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