Successful management of multi-focal hepatic infantile hemangioendothelioma using TACE/surgery followed by maintenance metronomic therapy

Sondhi, Vishal; Kurkure, Purna; Vora, Tushar; Banavali, Shripad; Vishwanathan, Satyashree; Medhi, Seema; Kulkarni, Anirudh; Quereshi, Sajid; Arora, Brijesh

doi:10.1136/bcr.12.2011.5456

Cited by 10 publications

(7 citation statements)

References 21 publications

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“…In case of the clinical triage of congestive heart failure, hepatomegaly and associated cutaneous hemangioma, a more aggressive therapy including steroids can be applied (35,36). The experience of successful use of metronomic therapy with cyclophosphamide and tamoxifen has been reported (37). In case of rapid deterioration of cardiac status or medical therapy failure, interruption of the arteriovenous shunt by hepatic artery embolization should be considered.…”

Section: Discussionmentioning

confidence: 99%

Infantile hepatic hemangioendothelioma: Report of two cases

et al. 2013

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We described two cases of infantile hepatic hemangioendothelioma: one with a solitary lesion and the other with multicentric lesions. Clinical presentation was with no liver symptoms in case 1, and hepatomegaly, failure to thrive, and palpable abdominal mass in case 2. Diagnostic imaging revealed single tumor formation in case 1 and multiple nodules in the liver in case 2. Dilemmas related to nature of the tumor were solved by microscopic analysis. The patient with the clinical appearance of a single lesion was successfully operated. The patient with multiple lesions in the liver tissue showed complete involution after corticotherapy.

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Section: Discussionmentioning

confidence: 99%

Infantile hepatic hemangioendothelioma: Report of two cases

et al. 2013

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“…However, surgical treatment remains controversial in symptomatic patients because the disease is benign, and some patients may recover completely with conservative treatment. 2 , 17 , 18 , 37 – 40 …”

Section: Discussionmentioning

confidence: 99%

Infantile hepatic haemangioendothelioma resection in a newborn: A case report and literature review

et al. 2020

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Infantile hepatic haemangioendothelioma (IHH) is the most common benign hepatic tumour in infants. However, experience of managing IHH is lacking and treatments for symptomatic IHH are controversial. Here we report the case of a patient with IHH treated by liver resection. A liver mass was found in a newborn by prenatal ultrasonography. The patient presented with abdominal distention with a tangible mass. Further imaging diagnosis and biopsy were carried out and complete surgical resection of the mass was performed. Histological examination confirmed IHH. The patient recovered uneventfully after surgery, with no additional therapy after discharge and no recurrence during follow-up. We also summarise previously published resected cases of IHH and review the surgical outcomes. Surgical resection and liver transplantation appear to be effective treatments for symptomatic IHH.

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“…These treatment options have presented serious and well-known side effects and variable rates of success. Refractory cases may require surgical management or even a combined approach of medical and surgical therapy [1, 10]. Due to the higher risk of complications and death, diffuse IHH patients may also require hepatic transplantation [1].…”

Section: Discussionmentioning

confidence: 99%

Diffuse infantile hepatic haemangioma—how to manage an incidental but potentially lethal finding

Rodrigues

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Costa

et al. 2018

Oxford Medical Case Reports

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Infantile hepatic haemangioma (IHH) is a rare vascular tumour that is potentially lethal due to its associated complications, including heart failure, hepatic failure, hypothyroidism and abdominal compartment syndrome. The authors report a case of an asymptomatic diffuse IHH in a newborn male, which was presented as an incidental finding at the time that the patient was diagnosed with pyloric stenosis. The patient was treated with increasing doses of propranolol that were well tolerated. With the regression of the IHH by the time that the patient reached one year of age, there was a significant imagiologic improvement. Because there is no consensus on the optimal approach for the treatment of liver tumours in newborns, it is important to adopt a systematic approach. After the diagnosis of diffuse IHH has been established, the decision to initiate treatment and the therapeutic of choice is often controversial. Regular follow-up is recommended to monitor possible complications.

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Successful management of multi-focal hepatic infantile hemangioendothelioma using TACE/surgery followed by maintenance metronomic therapy

Cited by 10 publications

References 21 publications

Infantile hepatic hemangioendothelioma: Report of two cases

Infantile hepatic hemangioendothelioma: Report of two cases

Infantile hepatic haemangioendothelioma resection in a newborn: A case report and literature review

Diffuse infantile hepatic haemangioma—how to manage an incidental but potentially lethal finding

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