Successful management of primary non Hodgkins lymphoma of the cranial vault

Abstract

Primary bone lymphoma (PBL) is a relatively uncommon entity. However, involvement of the cranial vault is an unusual manifestation of aggressive non-Hodgkin’s lymphoma. We report the case of a 42-year old immunocompetent woman who presented with an enlarging mass involving the right parietal bone. Magnetic resonance imaging (MRI) of the brain revealed an expansive tumor that affects the right parietal bone. Computed tomographic (CT) scans of the abdomen, chest and pelvis were negative for lymphadenopathy or organomegaly. Biopsy of the mass showed diffuse large B-cell non-Hodgkin’s lymphoma confirmed by immunohistochemical study. The patient had a complete response after 4 cycles of chemotherapy followed by external beam radiotherapy. After a follow-up of more than 9 months the patient is still in good local control without distant metastasis. The aim of our work is to report a case of Primary bone lymphoma of the cranial vault with good response to treatment combining sequential chemotherapy and radiotherapy.

A 60-Year-Old Indian Male With Altered Sensorium and Extensive Lymphoma of the Scalp

“…38 For primary lymphomatous tumors of the scalp and cranial vault, the clinical signs and symptoms are quite similar. 14,25,39–44 Most patients will present with an enlarging subcutaneous scalp mass, along with symptoms of headache, localized scalp pain, fatigue, and neurological complaints if the underlying brain is involved, such as seizures, confusion, and focal weakness. Therefore, based on the clinical features, the clinician cannot tell if the lymphomatous involvement of the scalp and cranium is from a metastatic process or a primary tumor.…”

Primary Bone Burkitt’s like Lymphoma of the Skull Mimicking Meningioma - Case Report and Review of Literature

“…Our patient was diagnosed at the age of 26, much younger than the median age of this population which was 48 years in 19 similar cases of primary bone lymphoma of the skull which we reviewed [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22].…”

“…The clinical presentation was the most commonly seen with skull lymphoma, where most cases reviewed also presented with a scalp lump or swelling [6][7][8][9][10][11][12][13], [15,21,22].…”

“…Most of the cases reviewed were treated with a low intensity chemotherapy regimen similar to CHOP or CEOP with or without Rituximab [7][8][9][10][11][12][13][14][15][16][17][18][19][20] and one case was treated with high dose methotrexate [17].…”

A case of primary skull lymphoma: Review of literature

“…Subgaleal with epidural component Jovit et al [21] 50/M NIC HD+BE. Subgaleal with subdural component Zouhour et al [22] 42 …”